IIVS | 2017
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October 2017

IIVS BCOP Training Video – Spanish

October 16, 2017
This 13- minute video demonstrates how to perform the BCOP assay according to the Test Guidelines set forth for the assay by the Organization for Economic Co-operation and Development (OECD TG 437). The video focuses on steps that are critical to the success of the assay such as handling of the isolated cornea and removal of the test material from the cornea at the conclusion of the exposure time....

IIVS and Colgate-Palmolive Team Up to Provide Training on Non-Animal Methods in Brazil

October 10, 2017
GAITHERSBURG, MD – Oct. 10, 2017 – IIVS, supported by a grant from Colgate-Palmolive, held a training course this month in Goiania, Brazil focused on two in vitro methods with international regulatory acceptance status. The course, Alternative Methods for Evaluation of Toxicity, was attended by over 30 participants from industry and government who participated in both lectures and hands-on exercises. The training course was organized as a satellite workshop to the Congress of Brazilian Toxicology, CBTox, in Goias, Brazil. In recent...

The 3T3 Neutral Red Uptake Phototoxicity Test – Spanish

October 6, 2017
This new training video explores a cell-based method for assessing Phototoxicity - or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to video...

Chinese FDA and IIVS Re-affirm Their Collaboration for Non-animal Tests

September 7, 2017
GAITHERSBURG, MD – Sept. 7, 2017 – Bo Li, General Director of the CFDA’s National Institute for Food and Drug Control (NIFDC) and Erin Hill, President of US based non-profit, Institute for In Vitro Sciences, Inc. (IIVS), signed a Memorandum of Understanding (MOU) to bring non-animal test methods to China for the regulation of cosmetics and ingredients. The move re-affirms and expands a three-year partnership between the NIFDC and IIVS. Currently China has mandatory animal testing for many products, including special...

Quality Considerations: Redefining Test Systems from Animals to Tissues and Beyond

August 28, 2017
Presented at the 2017 World Congress on Alternatives and Animals in the Life Sciences (WC10) A.K. Ulrey, RQAP-GLP; H.A. Raabe, M.S. The use of non-whole animal test methods transforms the way regulatory requirements are applied in preclinical testing. Recent global regulatory initiatives emphasize the importance of transitioning to human relevant assays and test systems that do not use animals. When these methods are moved from research into the regulated arena, GLP principles must be followed. The GLPs were originally written in the...

Introducing the 3R Concepts into Pre-College Classrooms

August 28, 2017
Presented at the 2017 World Congress on Alternatives and Animals in the Life Sciences (WC10) N. Green, G.-E. Costin, A. Miller, S. Leary, K. Lewis    This poster provides a snapshot of precollege teachers (46) within the U.S.—gauging their knowledge and familiarity of the 3Rs and non-animal testing methods (i.e. in vitro methods), initiative to address the topic in the classroom, and their students’ level of interest in the topic. While recognizing the ethical considerations related to animal experimentation, the current generation...

Non-Animal Testing Approach to Address Biocompatibility Testing of Medical Devices Required by the United States Food and Drug Administration (US FDA)

August 28, 2017
Presented at the 2017 World Congress on Alternatives and Animals in the Life Sciences (WC10) E. Hill, R. Curren, and G.-E. Costin Starting in December 2015, personal lubricants must receive pre-market approval from the US FDA Center for Devices and Radiological Health (CDRH) in order to be sold in the US. Part of the testing battery for biocompatibility includes the in vivo Rabbit Vaginal Irritation (RVI) test. We have created an Industry Consortium comprised of personal lubricants manufacturers and are working collaboratively with...

Collaborative Effort Aims to Replace Rabbit Test for Personal Lubricant Products

August 23, 2017
Washington, D.C. — August 21, 2017 — A first-of-its kind collaborative project is underway to find a non-animal test method to replace the rabbit vaginal irritation test for personal lubricants. The U.S. Food and Drug Administration (FDA) gave the project a green light as part of the agency’s program aimed at modernizing the tests used to develop and evaluate medical devices. The work of the lubricant industry, the Institute for In Vitro Sciences (IIVS), the PETA International Science Consortium Ltd., and...

Observation Spots Available for 2018 Practical Methods Workshop

August 23, 2017
It's not too late to register for the 2018 Practical Methods in In Vitro Toxicology Workshop, Jan,16-19, at IIVS in Gaithersburg, MD. Observation spots are available for the intensive four-day workshop. Gain the scientific information and expertise you need to strategically integrate non-animal methods within your testing program.  Register now....

Collaborative Effort Aims to Replace Rabbit Test for Personal Lubricant Products

August 21, 2017
Study in Response to Consumer Demands for Humane Testing Washington, D.C. — August 21, 2017 — A first-of-its kind collaborative project is underway to find a non-animal test method to replace the rabbit vaginal irritation test for personal lubricants. The U.S. Food and Drug Administration (FDA) gave the project a green light as part of the agency’s program aimed at modernizing the tests used to develop and evaluate medical devices. The work of the lubricant industry, the Institute for In Vitro Sciences...