IIVS, Non Animal Testing, Alternative Test Methods, In Vitro Testing | Advances in Science: Next Generation of Lab Tools, Models and Testing Platforms Used in Predictive Toxicology
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Advances in Science: Next Generation of Lab Tools, Models and Testing Platforms Used in Predictive Toxicology

July 19, 2017

By Dr. Gertrude-Emilia Costin

Toxicology testing platforms represent the basis of the human health risk assessment process that determines
whether a material or product may induce harm to humans upon exposure. Historically, safety assessment of raw
ingredients or finished formulations has been performed using animal-based test methods (in vivo) that provide
whole organism responses to toxicants. Due to the large number of products launched by industry continuously,
modern toxicology shifted in recent years towards the use of novel, fast and reliable alternative methods, ranging
from in silico to in chemico or in vitro, of which some are validated for regulatory purposes. The manuscript
also addresses emerging technologies in the form of “organ/body-on-a-chip” platforms which announce to be
instrumental in allowing alternative systems to in vivo models to assess systemic toxic effects induced by chemicals.

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