Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS | Nicotine Characterization of an In Vitro Inhalation Exposure System Using Conventional and Next-Generation Tobacco Products: A US/UK Inter-Laboratory Comparison
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Nicotine Characterization of an In Vitro Inhalation Exposure System Using Conventional and Next-Generation Tobacco Products: A US/UK Inter-Laboratory Comparison

March 28, 2018

The US-FDA has regulatory authority over tobacco products, including conventional cigarettes and next generation products
(NGPs) such as e-cigarettes and tobacco heating products (THPs). There is a desire by the industry, regulator and animal
protection organizations to incorporate non-animal test methods for tobacco product and NGP assessment. When assessing
respiratory effects in vitro, reliable exposure systems that deliver aerosols to cellular/tissue cultures at the air-liquid interface
are needed.