Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS | Assays Dermal
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Archive

Registration Now Open for Practical Methods 2019

August 27, 2018
IIVS is excited to announce that registration is now open for our 2019 Practical Methods for In Vitro Toxicology Workshop. Space is limited so please book as soon as possible to guarantee your spot. ...

Modernization of EPA “6-Pack” of Acute Toxicity Tests Continues

July 27, 2018
The US Environmental Protection Agency (US EPA) continues to drive significant efforts in the United States to modernize the battery of acute toxicity tests classically known as the “6-pack.” Learn More....

Modernization of EPA “6-Pack” of Acute Toxicity Tests Continues

July 26, 2018
The US Environmental Protection Agency (US EPA) continues to drive significant efforts in the United States to modernize the battery of acute toxicity tests classically known as the “6-pack.” Known for many years as an “all in vivo” testing strategy for products registered under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), the 6-pack was revised in 2015 to include non-animal (in vitro/ex vivo) test methods for classification and labeling for Eye Irritation, both for commonly used household cleaning products...

Tiered In Vitro Testing Strategy For Assessing The Ocular and Dermal Irritation/Corrosion Potential of Pharmaceutical Compounds

July 23, 2018
Read our latest publication with Bristol-Myers Squibb regarding a tiered testing strategy for occupational hazards of pharmaceutical intermediates now published in the Cutaneous and Ocular Toxicology Journal. Irritation reactions are a frequently reported occupational illness. The potential adverse effects of pharmaceutical compounds (PCs) on employees' eyes and skin can now be assessed using validated in vitro methods. Our overall aim is to reduce animal testing by replacing the historically utilized in vivo test methods with validated in vitro test methods which accurately determine the ocular...

Webinar: Skin Tone Modulation: In Vitro Pre-clinical and Clinical Efficacy Testing Strategies and Innovative Solutions in Cosmetics

July 13, 2017
Addressing uneven skin tone often associated with photo-aging is a key area of interest in the cosmetic industry. The design of novel, safe, and efficacious actives and ingredients capable of inducing subtle changes in skin tone can be accomplished using modern, relevant and reliable pre-clinical testing strategies prior to clinical assessment. During this one-hour webinar, IIVS Study Director, Dr. Gertrude-Emilia Costin and Dr. Manpreet Randhawa, Principal Scientist at Johnson & Johnson, discuss optimized in vitro testing platforms using pigmented tissue models...

View Our Webinar on Skin Tone Modulation

June 30, 2017
View the recording and slides from our webinar on skin tone modulation that was held on Thurs., June 29. The one-hour webinar features IIVS study director, Dr. Gertrude-Emilia Costin, and Johnson & Johnson principal scientist, Dr. Manpreet Randhawa as they discuss optimized in vitro testing platforms using pigmented tissue models that assess the capacity of ingredients and formulations that impact skin tone.   ...

Navigating the Claim Substantiation Maze in Cosmetics Industry

June 15, 2017
Read this article by IIVS study director Dr. Gertrude-Emilia Costin and biologist Asha Shravanthi Pidathala in the June 2017 issue of Eurocosmetics.  The article examines modern, relevant, and reliable in vitro testing strategies using pigmented tissue models that assess the capacity of ingredients and formulations that impact skin tone.    ...

Toxicity Testing: Read Between the Lines

April 13, 2017
Skin toxicity testing  was the focus of a full-day seminar held during In-Cosmetics 2017. Attendees learned about everything from skin absorption and metabolism, to cytotoxicity, phototoxicity and sensitization. IIVS Study Director, Dr. Tinashe Ruwona, presented on integrated testing strategies to evaluate the skin sensitization potential of cosmetics. However, the biggest take-away from the seminar seemed to rest on how well the results of a study are understood. Read the full article.  ...

IIVS Attends In-Cosmetics Global

April 4, 2017
IIVS President, Erin Hill, and Study Director, Tinashe Ruwona are attending the In-Cosmetics Global meeting, April 4-6, in London.  Dr. Ruwona, who leads our skin sensitization screening program, presented during the Skin Toxicology Workshop. His presentation,  "Integrated Testing Strategies for Assessing the Skin Sensitization Potential of Cosmetics",  Dr. Ruwona explores the various test methods and how best to combine them to ensure consumer safety.  Read more....

Addressing the Assignment of US EPA Hazard Categories for Dermal Safety by a Revised Prediction Model of the Validated In Vitro Skin Irritation Test (OECD TG 439)

March 30, 2017
One of the current goals of the United States Environmental Protection Agency Office of Pesticide Programs (US EPA OPP) is to replace by non-animal testing methods as many of the endpoints of the battery of acute toxicity tests known as the “6-pack” as possible. One of the “6-pack” tests is the Draize rabbit test for dermal irritation. We investigated whether the validated in vitro Skin Irritation Test (SIT, OECD TG 439) can be used to determine US EPA OPP dermal...