Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS | Assays Phototoxicity
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Archive

Registration Now Open for Practical Methods 2019

August 27, 2018
IIVS is excited to announce that registration is now open for our 2019 Practical Methods for In Vitro Toxicology Workshop. Space is limited so please book as soon as possible to guarantee your spot. ...

Evaluation of Phototoxicity of Ocular Medical and Combination Devices

March 28, 2018
To address ocular device induced phototoxicity, an in vitro 3T3 Neutral Red Uptake Phototoxicity test (OECD 432) for chemicals has been modified. Soft contact lenses formulated with three different photo-absorbing compounds and chemical solutions of these compounds were evaluated....

The Assessment of Phototoxicity Using the 3T3 Neutral Red Uptake (NRU) Phototoxicity Assay and a Modified Photo-Direct Peptide Reactivity Assay (DPRA)

March 28, 2018
Alternative methods, including the validated 3T3 Neutral Red Uptake (NRU) Phototoxicity assay (OECD TG 432) may be used as a pre-clinical test to address phototoxicity. Currently, there are no validated alternative test methods to identify photoallergens; however, there are several validated alternative test methods to address skin sensitization, including the Direct Peptide Reactivity Assay (DPRA) (OECD 442C). To address photoallergy, we utilized the 3T3 Phototoxicity assay in combination with a modified photo-DPRA assay to determine if these assays were able...

View our Posters from SOT 2018

March 28, 2018
Thank you to all who visited our booth at the 2018 SOT meeting.  Our scientists presented several posters at the meeting. If you did not have an opportunity to view our posters, or would like to view them again, we now have them available here to view online. ...

IIVS Posters at SOT 2018

March 28, 2018
 2018 Society of Toxicology (SOT) Annual Meeting March 11-15, 2018 San Antonio, TX Thank you to all who visited us at the 2018 SOT meeting. View our posters presented at the meeting.  Respiratory Toxicology Nicotine Characterization of an In Vitro Inhalation Exposure System Using Conventional and Next-Generation Tobacco Products: A US/UK Inter-Laboratory Comparison Oral Irritation Assessment of Electronic Liquids Using an In Vitro Oral Testing Model Use of Ex Vivo Precision-Cut Lung Slices as a Screening Tool for Potential Respiratory Toxicity of E-Liquids Human In...

IIVS at SOT 2018

February 8, 2018
IIVS will have several events and posters at the upcoming SOT meeting, March 11-15, in San Antonio, TX.  The events and three of our five posters focus on our respiratory toxicology program in support of our new laboratory that opened in 2017.  Other posters examine topics in phototoxicity.  Be sure to visit our booth at the meeting - Booth #533.   View more details on our events and posters at SOT....

The 3T3 Neutral Red Uptake Phototoxicity Test Training Video – Chinese

November 21, 2016
This new training video explores a cell-based method for assessing Phototoxicity – or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UVA/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to video production...

The 3T3 Neutral Red Uptake Phototoxicity Test Training Video – Portuguese

November 21, 2016
This new training video explores a cell-based method for assessing Phototoxicity - or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to video...

Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology

October 18, 2016
This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides...

Reconstructed Human Epidermis (RHE) Models

August 24, 2016
The 3-D Phototoxicity assay uses 3-D reconstructed human epidermal (RHE) tissue constructs to evaluate the dermal phototoxicity potential of a test material. Toxicity is determined by measuring cytotoxicity [based on the relative conversion of MTT (3-[4,5 - dimethylthiazol-2-yl] - 2,5 - diphenyltetrazolium bromide)] in cultures treated with the test material in the presence or absence of UVA light. An advantage of using 3-D tissues to evaluate phototoxicity potential is that, unlike the 96-well phototoxicity assay, test materials are applied topically, so solids,...