IIVS, Non Animal Testing, Alternative Test Methods, In Vitro Toxicology | Assays Acute Respiratory Toxicity
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Pulmonary Models

August 24, 2016
The Respiratory Toxicology Program utilizes state-of-the-art in vitro and ex-vivo models of pulmonary (and related) tissue. Models available offer a range of testing types, including screening and high content analysis for complex events. The choice of cell line (including reporter cells), primary cells, or 3-dimensional tissues depends on the throughput desired and level of assessment needed. Consider our oral cavity tissues to also model ingestion exposures. Let IIVS guide you to the model best for you! Pulmonary cell lines are readily...

Chronic Respiratory Toxicity

August 24, 2016
Prolonged exposure of lung tissue to materials, inhaled or otherwise, may challenge the tissue leading to cell death or loss of viability over time. Other changes due to long term exposure or prolonged tissue challenge can manifest in a variety of key events and markers of disease. IIVS’s Respiratory Toxicology Program offers several pulmonary models that will allow the assessment of long term exposure and effects, with cultures that can be maintained for weeks or months. While assays used for acute toxicity...

Acute Respiratory Toxicity

August 24, 2016
Exposure of lung tissue to materials, inhaled or otherwise, may challenge the tissue leading to cell death or loss of viability. IIVS’s Respiratory Toxicology Program offers several pulmonary models that will allow the assessment of cytotoxicity or viability loss after tissue exposure to test articles. These acute toxicity endpoints are available for all pulmonary models utilized within Respiratory Toxicology. Cytotoxicity manifests as a loss of membrane integrity and results in the release of intracellular constituents. Respiratory tissue exposed to a test material...

Next Generation Tobacco Products

August 24, 2016
IIVS has a long-standing history of working with various industries to help establish or utilize in vitro models for the prediction of risk and the assessment of products under development. With the Food and Drug Administration extending its authority to all tobacco products (including e-cigarettes, cigars, and hookah) the tobacco industry is faced with the task of assessing product safety for product development and regulatory submission. Further, the manufacture of tobacco products may entail risk to workers that come in...

In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products

June 10, 2016
Source: IIVS Workshop, April 4-6, 2016 See also Assessment of In Vitro COPD Models for Tobacco Regulatory Science: Workshop Proceedings, Conclusions and Paths Forward for In Vitro Model Use from our Dec. 2014 workshop. ...

Workshop Report: Assessment of In Vitro COPD Models for Tobacco Regulatory Science

July 10, 2015
Source: IIVS December 2014 Workshop See also In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products from our April 2016 workshop....