IIVS | Assays Chronic Respiratory Toxicity
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Archive

Special issue of Applied In Vitro Toxicology: Next Generation Tobacco Products

March 10, 2017
Check out the recently released special issue of Applied In Vitro Toxicology: Application of In Vitro Toxicology Approaches for the Evaluation of Next-Generation Nicotine Products.  The issue includes several articles by IIVS scientists and other experts. View the issue online....

In Vitro Models Available for Testing of ENDS

February 20, 2017
Presented at the National Academies of Sciences, Engineering, and Medicine's (NAS) workshop on electronic nicotine delivery systems (ENDS), e-cigarettes....

Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology

October 18, 2016
This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides...

Goblet Cell Hyperplasia

August 24, 2016
The exposure of materials to the respiratory tract can result in a variety of tissue effects including irritation, inflammation and downstream effects such as goblet cell hyperplasia (GCH). GCH is the elevated expression of Goblet cells in the airway and is involved in various diseases that can lead to debilitation conditions. IIVS uses human reconstructed airway tissues (RHuA) from both MatTek and Epithelix to assess exposures that may lead to GCH as an indicator of risk to human health. A variety...

Chronic Respiratory Toxicity

August 24, 2016
Prolonged exposure of lung tissue to materials, inhaled or otherwise, may challenge the tissue leading to cell death or loss of viability over time. Other changes due to long term exposure or prolonged tissue challenge can manifest in a variety of key events and markers of disease. IIVS’s Respiratory Toxicology Program offers several pulmonary models that will allow the assessment of long term exposure and effects, with cultures that can be maintained for weeks or months. While assays used for acute toxicity...

Acute Respiratory Toxicity

August 24, 2016
Exposure of lung tissue to materials, inhaled or otherwise, may challenge the tissue leading to cell death or loss of viability. IIVS’s Respiratory Toxicology Program offers several pulmonary models that will allow the assessment of cytotoxicity or viability loss after tissue exposure to test articles. These acute toxicity endpoints are available for all pulmonary models utilized within Respiratory Toxicology. Cytotoxicity manifests as a loss of membrane integrity and results in the release of intracellular constituents. Respiratory tissue exposed to a test material...

Next Generation Tobacco Products

August 24, 2016
IIVS has a long-standing history of working with various industries to help establish or utilize in vitro models for the prediction of risk and the assessment of products under development. With the Food and Drug Administration extending its authority to all tobacco products (including e-cigarettes, cigars, and hookah) the tobacco industry is faced with the task of assessing product safety for product development and regulatory submission. Further, the manufacture of tobacco products may entail risk to workers that come in...