IIVS, Non Animal Testing, Alternative Test Methods, In Vitro Testing | Assays Goblet Cell Hyperplasia
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Holger Behrsing, PhD, Participates in Round Table Discussion on Non-Animal Approaches for Inhalation Toxicology

June 14, 2018
Holger Behrsing, PhD, was recently invited to participate in an expert round table discussion convened on the development and implementation of 21st century non-animal approaches to assess the toxicity of inhaled substances.  The discussion included perspectives from government, industry, nonprofit, and academic sectors on the advantages and challenges of using these approaches, ongoing efforts, and steps needed to gain widespread use and acceptance of these approaches. A transcript of the discussion has just been published in Applied In Vitro Toxicology, Vol....

In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products: Workshop Proceedings, Conclusions and Paths Forward for In Vitro Model Use

August 17, 2017
In 2009, the passing of the Family Smoking Prevention and Tobacco Control Act facilitated the establishment of the FDA Center for Tobacco Products (CTP), and gave it regulatory authority over the marketing, manufacture and distribution of tobacco products, including those termed ‘modified risk’. On April 4-6, 2016, IIVS convened a workshop conference entitled, In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products, to bring together stakeholders representing regulatory agencies, academia and industry to address the research priorities...

Special issue of Applied In Vitro Toxicology: Next Generation Tobacco Products

March 10, 2017
Check out the recently released special issue of Applied In Vitro Toxicology: Application of In Vitro Toxicology Approaches for the Evaluation of Next-Generation Nicotine Products.  The issue includes several articles by IIVS scientists and other experts. View the issue online....

In Vitro Models Available for Testing of ENDS

February 20, 2017
Presented at the National Academies of Sciences, Engineering, and Medicine's (NAS) workshop on electronic nicotine delivery systems (ENDS), e-cigarettes....

Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology

October 18, 2016
This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides...

Goblet Cell Hyperplasia

August 24, 2016
The exposure of materials to the respiratory tract can result in a variety of tissue effects including irritation, inflammation and downstream effects such as goblet cell hyperplasia (GCH). GCH is the elevated expression of Goblet cells in the airway and is involved in various diseases that can lead to debilitation conditions. IIVS uses human reconstructed airway tissues (RHuA) from both MatTek and Epithelix to assess exposures that may lead to GCH as an indicator of risk to human health. A variety...

Chronic Respiratory Toxicity

August 24, 2016
Prolonged exposure of lung tissue to materials, inhaled or otherwise, may challenge the tissue leading to cell death or loss of viability over time. Other changes due to long term exposure or prolonged tissue challenge can manifest in a variety of key events and markers of disease. IIVS’s Respiratory Toxicology Program offers several pulmonary models that will allow the assessment of long term exposure and effects, with cultures that can be maintained for weeks or months. While assays used for acute toxicity...