IIVS | Assays Pulmonary Models
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Archive

In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products: Workshop Proceedings, Conclusions and Paths Forward for In Vitro Model Use

August 17, 2017
In 2009, the passing of the Family Smoking Prevention and Tobacco Control Act facilitated the establishment of the FDA Center for Tobacco Products (CTP), and gave it regulatory authority over the marketing, manufacture and distribution of tobacco products, including those termed ‘modified risk’. On April 4-6, 2016, IIVS convened a workshop conference entitled, In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products, to bring together stakeholders representing regulatory agencies, academia and industry to address the research priorities...

Special issue of Applied In Vitro Toxicology: Next Generation Tobacco Products

March 10, 2017
Check out the recently released special issue of Applied In Vitro Toxicology: Application of In Vitro Toxicology Approaches for the Evaluation of Next-Generation Nicotine Products.  The issue includes several articles by IIVS scientists and other experts. View the issue online....

In Vitro Models Available for Testing of ENDS

February 20, 2017
Presented at the National Academies of Sciences, Engineering, and Medicine's (NAS) workshop on electronic nicotine delivery systems (ENDS), e-cigarettes....

Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology

October 18, 2016
This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides...

Goblet Cell Hyperplasia

August 24, 2016
The exposure of materials to the respiratory tract can result in a variety of tissue effects including irritation, inflammation and downstream effects such as goblet cell hyperplasia (GCH). GCH is the elevated expression of Goblet cells in the airway and is involved in various diseases that can lead to debilitation conditions. IIVS uses human reconstructed airway tissues (RHuA) from both MatTek and Epithelix to assess exposures that may lead to GCH as an indicator of risk to human health. A variety...

Pulmonary Models

August 24, 2016
The Respiratory Toxicology Program utilizes state-of-the-art in vitro and ex-vivo models of pulmonary (and related) tissue. Models available offer a range of testing types, including screening and high content analysis for complex events. The choice of cell line (including reporter cells), primary cells, or 3-dimensional tissues depends on the throughput desired and level of assessment needed. Consider our oral cavity tissues to also model ingestion exposures. Let IIVS guide you to the model best for you! Pulmonary cell lines are readily...

Chronic Respiratory Toxicity

August 24, 2016
Prolonged exposure of lung tissue to materials, inhaled or otherwise, may challenge the tissue leading to cell death or loss of viability over time. Other changes due to long term exposure or prolonged tissue challenge can manifest in a variety of key events and markers of disease. IIVS’s Respiratory Toxicology Program offers several pulmonary models that will allow the assessment of long term exposure and effects, with cultures that can be maintained for weeks or months. While assays used for acute toxicity...

Acute Respiratory Toxicity

August 24, 2016
Exposure of lung tissue to materials, inhaled or otherwise, may challenge the tissue leading to cell death or loss of viability. IIVS’s Respiratory Toxicology Program offers several pulmonary models that will allow the assessment of cytotoxicity or viability loss after tissue exposure to test articles. These acute toxicity endpoints are available for all pulmonary models utilized within Respiratory Toxicology. Cytotoxicity manifests as a loss of membrane integrity and results in the release of intracellular constituents. Respiratory tissue exposed to a test material...