IIVS, Non Animal Testing, Alternative Test Methods, In Vitro Testing | Assays LuSens
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IIVS and BASF Collaborate to Distribute Test Method to Replace Animal Testing in China

January 9, 2018
GAITHERSBURG, MD – January 9, 2018 – The Institute for In Vitro Sciences, Inc. (IIVS) today announced a collaboration with BASF to import a non-animal, cell based, safety test into China. The LuSens test, developed by BASF, is an in vitro test to detect the sensitization potential of chemicals to human skin. The test was developed to be license free and shared with the scientific community at-large. It has recently been incorporated into the Organization for Economic Co-operation and Development...

Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology

October 18, 2016
This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides...

LuSens (OECD 442D)

August 24, 2016
The LuSens assay is a “me-too” assay which addresses the cellular event of keratinocyte activation, similar to the KeratinoSens assay (OECD 442D).  It is a reporter gene bioassay using a human keratinocyte cell line.  IIVS participated in an inter-laboratory study led by BASF to assess the transferability, reproducibility, and accuracy of the method.  The results demonstrated an accuracy of greater than 80% in identifying skin sensitizers.  The study was published in Toxicology in Vitro in 2016.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...

Direct Peptide Reactivity Activation Assay (DPRA, OECD 442C)

August 24, 2016
The DPRA  (OECD 442C) is an in chemico assay that  models the first key event in the skin sensitization Adverse Outcome Pathway (AOP) - skin, protein reactivity. Compounds implicated in causing Allergic Contact Dermatitis (ACD) are generally electrophilic in nature. This assay identifies dermal sensitizers based on their reactivity with synthetic peptides containing the nucleophilic amino acid residues lysine and cysteine. Using LC/UV, conjugation of the test material with the peptides can be analyzed. Trained by the developers of this assay (Procter &...

KeratinoSens (OECD 442D)

August 24, 2016
The KeratinoSensTM assay is a cell-based reporter gene assay that models the second key event in the Adverse Outcome Pathway for Dermal Sensitization, namely keratinocyte activation. This approach measures the induction of luciferase under the control of the antioxidant response element (ARE) derived from the human AKR1C2 gene, and can be used in a Weight-of-Evidence approach as an alternative to animal testing methods for the purpose of hazard identification. IIVS has participated in validation studies led by the assay developer Givaudan, a multi-national...

Fragrance & Flavors

August 24, 2016
Exposure to fragrance chemicals is most commonly by direct skin contact. Allergic contact dermatitis (ACD) to fragrance ingredients is most often caused by cosmetic products, such as perfumes, deodorants, and aftershave products. Cosmetic fragrance ingredients should be assessed for exposure damage including skin sensitization (ACD), phototoxicity, skin irritation (irritant contact dermatitis), and respiratory irritation and sensitization. At IIVS, we have pre-clinical testing programs to address each of these endpoints to ensure the safety of fragrance 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...

Cosmetics & Personal Care

August 24, 2016
European legislation and US research activities towards ‘21st century toxicology’ are setting the standards for animal-free toxicological assessments and the cosmetics industry has been the first to feel the effects. As per EU Regulation 1223/2009, animal testing of cosmetic ingredients and finished products is currently banned in the EU, as is the marketing of finished cosmetic products and the ingredients contained therein which were tested on animals for cosmetic safety assessment purposes. These bans hold irrespective of the availability of validated...

Agro/Petrochemical

July 28, 2016
Agricultural chemicals consist of multiple product types including fertilizers, pesticides, and herbicides. As a result, these chemicals can cover a wide range in the irritation spectrum, from materials that are classified as mild irritants to those that are designated as corrosive. Classification is needed for registration through organizations such as the US EPA, REACH, or Brazil ANVISA. Multiple in vitro assays have OECD test guidelines that can be used to provide GHS hazard classifications that may meet necessary testing requirements. Ocular...

Webinar: Regulatory Initiatives for New Approaches to Traditional Toxicity Testing

July 1, 2016
This one-hour webinar features presentations by Dr. Jennifer McLain, Deputy Director, Office of Pesticide Programs, Antimicrobial Division and IIVS CEO Dr. Rodger Curren. Dr. McLain discusses the EPA OPP's plans to reduce the use of animal testing in acute toxicity testing and provides suggestions on how stakeholders and EPA can cooperate to advance animal reduction goals. Dr. Curren then talks about IIVS' activities in developing the current non-animal strategy for eye irritation, and recent investigations into in vitro methods to...