IIVS | Industries Cosmetic & Personal Care
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The 3T3 Neutral Red Uptake Phototoxicity Test Training Video – Portuguese

November 21, 2016
This new training video explores a cell-based method for assessing Phototoxicity - or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to video...

Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology

October 18, 2016
This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides...

Advancing Non-animal Testing Methods: First Set of Novel Knowledge Tools Published

October 18, 2016
An adverse outcome pathway, or AOP, is a highly structured way of describing a toxicological process which can lead to an adverse health effect in humans or wildlife, caused by an unsafe exposure to a chemical substance. The first five adverse outcome pathways have now been published by experts. The AOPs are novel knowledge management tools in toxicology and are useful for supporting risk assessment to human health. They are also valuable for helping to avoid animal testing through the...

IIVS Announces Suite of Non-Animal Methods to Reduce Animal Testing for Skin Sensitization

September 6, 2016
GAITHERSBURG, MD – September 6, 2016 – In response to a newly published OECD Test Guideline, IIVS announces the addition of the Human Cell Line Activation Test (h-CLAT, OECD TG 442E) to its suite of non-animal assays to determine skin sensitization. The assessment of skin sensitization has historically involved the use of laboratory animals; specifically guinea pigs and mice. In recent years, international research and validation efforts have paved the way for the use of non-animal methods. “Industry has provided the field...

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August 30, 2016
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NociOcular Eye Sting

August 24, 2016
The NociOcular Assay predicts the eye stinging potential of materials, such as cosmetics, sunscreens, surfactants, and ophthalmic products. The assay relies on the expression of functional Transient Receptor Potential Vanilloid type 1 (TRPV1) channels in a clone of the human SH-SY5Y neuroblastoma cell line. The TRPV1 channel is a well characterized pain receptor that is present in tissues associated with the eye. This channel can be activated by chemical stimuli and is thought to be a general mediator of chemically...

Cosmetics & Personal Care

August 24, 2016
European legislation and US research activities towards ‘21st century toxicology’ are setting the standards for animal-free toxicological assessments and the cosmetics industry has been the first to feel the effects. As per EU Regulation 1223/2009, animal testing of cosmetic ingredients and finished products is currently banned in the EU, as is the marketing of finished cosmetic products and the ingredients contained therein which were tested on animals for cosmetic safety assessment purposes. These bans hold irrespective of the availability of validated...

Webinar: Regulatory Initiatives for New Approaches to Traditional Toxicity Testing

July 1, 2016
This one-hour webinar features presentations by Dr. Jennifer McLain, Deputy Director, Office of Pesticide Programs, Antimicrobial Division and IIVS CEO Dr. Rodger Curren. Dr. McLain discusses the EPA OPP's plans to reduce the use of animal testing in acute toxicity testing and provides suggestions on how stakeholders and EPA can cooperate to advance animal reduction goals. Dr. Curren then talks about IIVS' activities in developing the current non-animal strategy for eye irritation, and recent investigations into in vitro methods to...