Archive

Next Generation Tobacco Products

August 24, 2016
IIVS has a long-standing history of working with various industries to help establish or utilize in vitro models for the prediction of risk and the assessment of products under development. With the Food and Drug Administration extending its authority to all tobacco products (including e-cigarettes, cigars, and hookah) the tobacco industry is faced with the task of assessing product safety for product development and regulatory submission. Further, the manufacture of tobacco products may entail risk to workers that come in... 3T3 Neutral Red Uptake | Acute Respiratory Toxicity | Bronchial/Tracheal | Chronic Respiratory Toxicity | Ciliary Beat Frequency | DPRA | Eye Irritation Test | Goblet Cell Hyperplasia | Inflammatory Biomarker Profiling | Inflammatory Cytokine Expression

In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products

June 10, 2016
Source: IIVS Workshop, April 4-6, 2016 See also Assessment of In Vitro COPD Models for Tobacco Regulatory Science: Workshop Proceedings, Conclusions and Paths Forward for In Vitro Model Use from our Dec. 2014 workshop. ... Acute Respiratory Toxicity | Chronic Respiratory Toxicity | Ciliary Beat Frequency | Goblet Cell Hyperplasia | Inflammatory Biomarker Profiling | Respiratory Toxicology | Tobacco

IIVS Workshop Explores Exposure and Dosimetry Considerations for Non-animal Testing

April 12, 2016
GAITHERSBURG, MD – April 12, 2016 – The Institute for In Vitro Sciences (IIVS) brought together stakeholders from industry, government and academia to discuss considerations for exposure and dosimetry for non-animal testing during its 2.5-day workshop, “In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products”, held April 4-6, 2016 in Bethesda, MD. Uniquely focused on in vitro testing, the workshop is the only known event of its kind. Attendees, including toxicologists from industry, the FDA Center for Tobacco... Tobacco

Digital Dispensing onto 3D Airway Tissue: Delivery of Patterned, Picoliter Volumes for Direct Apical Surface Coverage with Precise Quantities of Test Material

April 4, 2016
Source: In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacc…... Acute Respiratory Toxicity | Bronchial/Tracheal | Household & Consumer Products | Tobacco

Effect of Acclimation Conditions on 3D Human in vitro ALI Airway Models: Exposure-induced Inflammatory Response and Sampling Location-specific Results

March 15, 2016
Source: SOT 2016... Acute Respiratory Toxicity | Bronchial/Tracheal | Household & Consumer Products | Tobacco

2014 CORESTA: Toxic Insult to Rat Precision Cut Lung Slices

March 10, 2016
Source: CORESTA 2014... Bronchial/Tracheal | Precision Cut Lung Slices (PCLS) | Pulmonary Models | Household & Consumer Products | Tobacco

2014 TSRC Lung Slices for COPD

March 10, 2016
Source: TRSC 2014... Bronchial/Tracheal | Chronic Respiratory Toxicity | Tobacco

Overview: Etiology of COPD and In Vitro Models

March 10, 2016
... Bronchial/Tracheal | Chronic Respiratory Toxicity | Tobacco

Detection of Inflammation and Parenchymal Damage Using Precision-cut Lung Slices

March 10, 2016
... Bronchial/Tracheal | Precision Cut Lung Slices (PCLS) | Pulmonary Models | Household & Consumer Products | Tobacco

3D Reconstructed Human Airway Models: Effect of Acclimation Conditions on Biomarker and Inflammatory Response Following Tissue Challenge

March 10, 2016
Source: TRSC 2015... Acute Respiratory Toxicity | Bronchial/Tracheal | Tobacco