IIVS | Cytotoxicity
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Cytotoxicity

Neutral Red Uptake

The Normal Human Epidermal Keratinocytes (NHEKs) Cytotoxicity Assay using a Neutral Red Uptake (NRU) viability endpoint is a 96-well cytotoxicity assay to assess the toxicity potential of a test material. The assay utilizes primary NHEK cells and may be used to predict either human lethal serum concentrations or in vivo rodent LD50starting doses for acute oral systemic...

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AGAR Overlay

AGAR Overlay, Cytotoxicity Assay for Devices and Device Extracts The agar overlay assay or agar diffusion test is an in vitro cytotoxicity assay designed to show the presence of toxic material eluted from a test sample as it affects L929 cells cultured in the presence of the test article. Test articles are placed onto the...

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NHEK & 3T3

The 3T3 Neutral Red Uptake (NRU) Cytotoxicity Assay using a Neutral Red Uptake (NRU) viability endpoint is a 96-well cytotoxicity assay to assess the toxicity potential of a test material. The assay utilizes Balb/c 3T3 mouse fibroblasts to assess the systemic toxicity potential of a test material and may be used to predict in vivo rodent LD50 starting...

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MEM Elution

The MEM elution assay or elution test is an in vitro cytotoxicity assay designed to show the presence of toxic material eluted from a test sample as it affects L929 cells cultured in the presence of the extract. Extracts of test articles are applied to L929 cells.  After treatment, the cells are exposed to neutral...

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