IIVS | Dermal
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UV Induced Toxicity

Test materials that absorb light in the UVB, UVA, and visible light range and are topically applied to or may be distributed to sun exposed areas of the skin should be considered for photosafety evaluation.  Test materials that are phototoxic can produce adverse effects in the presence of light after exposure. At IIVS, we perform two...

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Corrositex (OECD 435)

The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex kit, manufactured by In Vitro International (IVI), uses a proprietary biobarrier membrane to model the skin for evaluating the potential dermal corrosivity of a test material. A test material is evaluated based on its penetration through...

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Pigmentation & Melanogenesis

The efficacy of ingredients or final formulations in modulating human skin pigmentation can be assessed in vitro by analysis of melanin production in reconstructed tissue models of various phototypes. In addition, this testing platform is suitable for investigation of the dermal irritation potential of test materials after repeated exposures using a tissue viability endpoint. The...

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Skin Irritation Test (SIT, OECD 439)

Skin Irritation Test (SIT) in a Reconstructed Human Epidermis (RhE) Model Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable...

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Irritation Screening

Product development/product stewardship scientists and formulators typically find it desirable to compare or rank order the skin irritation potential of candidate formulations, or to monitor the impact of changes in formulations or ingredients on skin tolerance.  Foremost, industry researchers need timely, accurate, cost-effective test results to help them get safer products to the marketplace. The...

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Inflammatory Cytokine Expression

Product Safety Assessment Using an In Vitro Test System Based on Viability of and Cytokine Released by Reconstructed Human Epidermis (RhE) Models Assay used for the evaluation of the skin irritation potential of topically administered test materials Frequently used to address the irritation profile of (but not limited to) surfactant-based formulations with rinse-off applications The...

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Skin Corrosion Test (OECD 431)

Skin Corrosion in the regulatory hazard classification and labeling context is defined as the production of irreversible damage to skin, generally evident as necrosis through the epidermis and into the dermis, following a defined chemical exposure. The In Vitro Skin Corrosion Test is an in vitro, non-animal test designed to identify those chemicals and mixtures...

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