IIVS, Non Animal Testing, Alternative Test Methods, In Vitro Testing | LuSens (OECD 442D)
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LuSens (OECD 442D)

The LuSens assay is a “me-too” assay which addresses the cellular event of keratinocyte activation, similar to the KeratinoSens assay (OECD 442D).  It is a reporter gene bioassay using a human keratinocyte cell line.  IIVS participated in an inter-laboratory study led by BASF to assess the transferability, reproducibility, and accuracy of the method.  The results demonstrated an accuracy of greater than 80% in identifying skin sensitizers.  The study was published in Toxicology in Vitro in 2016.