The ability to ascertain the maximum limit of a compound that can be applied to the skin without inducing skin sensitization is a critical safety criterion to virtually any risk assessment. Using regression models developed by Givaudan, IIVS is able to perform a computational approach to determine predicted EC3 values (Effective Concentration required to induce a 3-fold upregulation of lymph node cell proliferation) using a combination of OECD approved NAMs (KeratinoSens, hCLAT, and kDPRA). This value can be used to assess risk for compounds to be included in formulations.

Publications

Integrated Skin Sensitization Assessment Based on OECD Methods (I): Deriving a Point of Departure for Risk Assessment

Integrated Skin Sensitization Assessment Based on OECD Methods(II): Hazard and Potency by Combining Kinetic Peptide Reactivity and the “2 out of 3” Defined Approach 

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