Genetic Toxicology
Reconstructed Skin Micronucleus (RSMN)
Reconstructed Skin Micronucleus (RSMN) Using the EpiDerm™ Reconstructed Human Epidermis Model RSMN is used to evaluate the genotoxicity potential of the test article to the EpiDerm™ Skin Model. Genotoxicity potential is determined by assessing whether the micronucleus frequency in tissues exposed to the test article showed a statistically significant increase relative to the tissues exposed...
Bhas 42 Cell Transformation Assay
Bhas 42 Cell Transformation Assay (Bhas 42 CTA) The Bhas 42 CTA is used to evaluate the carcinogenic potential (tumor-initiating activity and/or -promoting activity) of genotoxic or non-genotoxic test articles. The untransformed Bhas 42 cells grow to confluence forming a density-dependent contact-inhibited monolayer. A carcinogenic stimulus induces morphological alterations and leads to the formation of...
ToxTracker®
ToxTracker® is a unique, stem-cell based assay which takes advantage of a Green Fluorescent Protein (GFP) reporter system to identify hazard and mode-of-action (MOA) of potentially genotoxic materials. ToxTracker has been extensively validated to predict in vivo genotoxic substances with an accuracy of more than 90%. Over 1,500 compounds have been successfully evaluated with the...