Genetic Toxicology

Reconstructed Skin Micronucleus (RSMN)

Reconstructed Skin Micronucleus (RSMN) Using the EpiDerm™ Reconstructed Human Epidermis Model RSMN is used to evaluate the genotoxicity potential of the test article to the EpiDerm™ Skin Model. Genotoxicity potential is determined by assessing whether the micronucleus frequency in tissues exposed to the test article showed a statistically significant increase relative to the tissues exposed...

Read more ...

Bhas 42 Cell Transformation Assay

Bhas 42 Cell Transformation Assay (Bhas 42 CTA) The Bhas 42 CTA is used to evaluate the carcinogenic potential (tumor-initiating activity and/or -promoting activity) of genotoxic or non-genotoxic test articles. The untransformed Bhas 42 cells grow to confluence forming a density-dependent contact-inhibited monolayer. A carcinogenic stimulus induces morphological alterations and leads to the formation of...

Read more ...