Photo-Direct Peptide Reactivity Assay

The in chemico photo-DPRA incorporates a light exposure step into the standard DPRA protocol to determine if a compound becomes photoreactive in the presence of light. Peptide depletion is measured after exposure to a compound in the presence and absence of UVA/visible light. In addition, because the assay includes a standard 24 hour exposure without irradiation, the assay can provide insight into skin sensitization potential.