Ciliary Beat Frequency
Mucociliary clearance is a primary innate defense mechanism that helps with the expulsion of inhaled foreign particles and chemicals from the airways via mucociliary escalator. Ciliary beat frequency (CBF) is a key factor in determining the rate of mucus clearance and maintaining lung health. An altered CBF or diminished active area of ciliary beating reflects impaired clearance. IIVS uses the SAVA system to determine CBF and active area in RHuA tissues following exposures to test materials.