Predicted EC3 Evaluation/Potency Assessment

The ability to ascertain the maximum limit of a compound that can be applied to the skin without inducing skin sensitization is a critical safety criterion to virtually any risk assessment. Using regression models developed by Givaudan, IIVS is able to perform a computational approach to determine predicted EC3 values (Effective Concentration required to induce a 3-fold upregulation of lymph node cell proliferation) using a combination of OECD approved NAMs (KeratinoSens, hCLAT, and kDPRA). This value can be used to assess risk for compounds to be included in formulations.

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