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PublicationOptimizations of the Reconstructed Human Epidermis-Based Phototoxicity Testing to Evaluate the Safety of Long-Lasting Cosmetic Products
The safety of cosmetic products coming in contact with consumers’ skin is often assessed using New Approach Methodologies, which include Reconstructed human Epidermis (RhE)...
January 10, 2025 -
PublicationA Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods
There is increased interest in developing non-animal test systems for inhalation exposure safety assessments. However, defined methodologies are absent for predicting local...
January 08, 2025 -
Poster/PresentationBuilding Confidence and Transparency Into a New Validation Paradigm
For the last two decades, validation management organizations have evaluated new test methods according to the OECD’s Guidance Document 34: Guidance Document On The Validation...
November 26, 2024
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Human relevance of in vivo and in vitro skin irritation tests for hazard classification of pesticides
Test methods to inform hazard characterization and labeling of pesticides to protect human health are typically conducted using laboratory animals, and for skin irritation/corrosion...
September 24, 2024 -
The Fibrotic Phenotype of Human Precision-Cut Lung Slices Is Maintained after Cryopreservation
Human precision-cut lung slices (hPCLS) prepared from fibrotic lungs recapitulate the pathophysiological hallmarks of fibrosis. These hallmark features can also be induced...
September 24, 2024 -
Deriving a point of departure for assessing the skin sensitization risk of wearable device constituents with in vitro methods
Wearable devices are in contact with the skin for extended periods. As such, the device constituents should be evaluated for their skin sensitization potential, and a Point...
September 24, 2024