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Krumdieck MD4000 slicer
Krumdieck MD4000 slicer Tag
Increased Throughput and Cryopreservation of Precision-cut Lung Slices Extend the Utility of Human-relevant, 3-Dimensional Pulmonary Test Systems
March 18, 2019
Human-relevant, in vitro/ex vivo assays are considered an ethical and economically viable manner by which to screen the thousands of chemicals requiring hazard assessment. Of the 3-dimensional models, human precision-cut lung slices (PCLS) are often considered the most physiologically relevant pulmonary test system, but lower throughput and difficulties in cryopreservation have hampered PCLS use. We have modified a tissue slicer to accommodate 3 tissue cores for simultaneous slicing. Increased slice production was quantified using agarose and tissue cores in the slicer....
Acute Respiratory Toxicity
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Chronic Respiratory Toxicity
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Precision Cut Lung Slices (PCLS)
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Pulmonary Models
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Respiratory Toxicology
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WST-8
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Agro/Petrochemical
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Cleaning Products
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Household & Consumer Products
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Occupational Safety & Industrial Hygiene