Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS | 2014 January
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January 2014

Predicting Ocular Irritation of Surfactants Using the Bovine Corneal Opacity and Permeability Assay

January 1, 2014
The Bovine Corneal Opacity and Permeability (BCOP) assay is an ex vivo test used to evaluate ocular irritation. According to the OECD Test Guideline (TG) 437, the BCOP assay can be used to identify chemicals which induce severe/corrosive eye irritation and those that do not require classification. However, BCOP has historically under-predicted certain anionic surfactants, when tested according to the standard liquid protocol. Since neither the basis for selecting the appropriate surfactant test methods, nor the justification for modifications are...