May 22, 2023
IIVS is excited to announce a new publication in Science with co-authors at Boston University and Mechanobiologix (Newton, MA, USA)! Abstract: Emphysema is a debilitating disease that remodels the lung leading to reduced tissue stiffness. Thus, understanding emphysema progression requires assessing lung stiffness at both the tissue and alveolar scales. Here, we introduce an approach to determine multiscale tissue stiffness and apply it to precision-cut lung slices (PCLS). First, we established a framework for measuring stiffness of thin, disk-like samples....
March 31, 2023
IIVS presented several posters at SOT 2023. This post includes links to the full PDF versions of each poster presented.
Application of a Performance Characterization Protocol for the Assessment of Normal and Diseased Cryopreserved Human Precision-Cut Lung
Evaluation and Transferability of a New Approach Methodology to Address Photoallergy
Evaluation of Complex Compounds in the UV-Vis Absorption Spectra
General Behaviors of Surfactants in the Bovine Corneal Opacity and Permeability
Modifications in the RhE Phototoxicity Assay to Evaluate Long-Lasting Cosmetic Products
Optimization of an In Vitro Preclinical Screening...
February 23, 2023
The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific and technical approaches for conducting in vitro assays, to assess potential toxicity within and across tobacco and various next generation nicotine and tobacco products (NGPs), including heated tobacco products (HTPs) and electronic nicotine delivery systems (ENDS). The third workshop (24–26 February 2020) summarised the key challenges and made recommendations concerning appropriate methods of test article generation and cell exposure from...
October 19, 2022
Ludwigshafen, Germany and Gaithersburg, Maryland, USA – October 19, 2022 – The Institute for In Vitro Sciences (IIVS) certified BASF’s Experimental Toxicology and Ecology for Good In Vitro Method Practices (GIVIMP) based on the guidance document published in 2018 by the Organization of Economic Cooperation and Development (OECD). The GIVIMP document provides principles in quality management which, when implemented, serve to increase the quality and confidence in data generated by in vitro test methods.
October 7, 2022
The Organization for Economic Cooperation and Development (OECD) guidance document on Good In Vitro Method Practices (GIVIMP) details a set of quality standards to improve both the quality of and confidence in newly developed, and routinely executed in vitro methods. Currently a practical guide to implement GIVMP standards is missing; leaving organizations to define the best approach for themselves.
July 1, 2022
The ability to ascertain the maximum limit of a compound that can be applied to the skin without inducing skin sensitization is a critical safety criterion for virtually any risk assessment. Using regression models developed by Givaudan (Kempthal, Switzerland), IIVS is able to perform a computational approach to determine predicted EC3 values (Effective Concentration required to induce a 3-fold upregulation of lymph node cell proliferation) using a combination of OECD approved assays (KeratinoSens, hCLAT, and kDPRA). This value can be used to assess risk for compounds to...
April 14, 2022
Thank you to all who visited our booth or poster sessions at the 2022 Society of Toxicology annual meeting. If you would like copies of any of the poster presented we now have them available to view online:
Compatibility Determination of Alternative Solvents in the human Cell Line Activation Test (h-CLAT) for the Assessment of Skin Sensitization
Cryopreservation of Human Precision-Cut Lung Slices Provides an Immune Competent, Pulmonary Test System for “On-Demand” Use
Modification in Procedure of the Reconstructed Human EpiDermis (RhE) Phototoxicity Assay
March 4, 2021
IIVS is pleased to see China providing a pathway for the importation of certain cosmetics without #animaltesting. The pathway does contain certain requirements that the international community must strive to meet - but it is certainly a major step forward. IIVS will continue its outreach with China's National Institute for Food and Drug Control (NIFDC), as well as with provincial FDA's, to continue to implement #nonanimal methods into their regulatory guidelines. Thank you to all our great contributors who fund this important work!...
September 28, 2020
IIVS is pleased to announce that Allison Hilberer will participate in the OECD Test Guidelines Programme Expert Groups (OECD TG EG) for eye and skin irritation, phototoxicity and skin sensitization. Allison is a Toxicologist II and Study Director at IIVS where she oversees the conduct of in vitrostudies in these areas. Allison has also been involved in many validation programs and participated in efforts to draft and revise OECD Test Guidelines. Read Post...