September 2021

IIVS e-News – September 2021

September 16, 2021
It’s been a very exciting year in the field of New Approach Methodologies (NAMs) with the release of the OECD 497 and 498 Test Guidelines which have codified Defined Approaches for Skin Sensitization and the Reconstructed Human Epidermis Phototoxicity Test, respectively....

Participation at the 2021 Annual Meeting of the American Society for Cellular and Computational Toxicology is Complimentary This Year!

August 2, 2021
As we are once again meeting online, we are pleased to announce that access to the 2021 meeting will be FREE for all attendees. However, if you are interested in helping further ASCCT’s activities, please consider becoming a member—one-year memberships for students are only $20 USD, and individual memberships are $50 USD. By joining as a member, you will have early-bird access to register for our monthly webinars, as well as receive exclusive industry-specific job postings and other relevant opportunities shared...

IIVS e-News – July 2021

June 30, 2021
The Defined Approaches (DAs) to Skin Sensitization Test Guideline cites 2 strategies which can be used to evaluate hazard potential of compounds and 1 strategy to evaluate GHS potency. The hazard DAs involve in vitroapproaches to the evaluation of sensitization using multiple assays which evaluate different steps in the Adverse Outcome Pathway. Both the "2 out of 3" (Fig 1) and "Key Event 3/1" approaches (Fig 2) have been included in the OECD Test Guideline. The potency assessment is an...

IIVS e-News – May 2021

May 6, 2021
IIVS and the Research Institute for Fragrance Materials (RIFM) have initiated a collaboration to develop tests designed to assess potential respiratory allergens. Developing a reliable, in vitroassay to assess the allergenicity of materials to the airway tract has been an area of active research for well over a decade, however most efforts have resulted in poor accuracy and the inability to distinguish airway sensitizers from irritants. By combining the extensive expertise and knowledge base in the field of respiratory toxicology...

How a GIVIMP Certification Program Can Increase Confidence in In Vitro Methods

April 20, 2021
Regulatory bodies, validation authorities, method developers, and industry toxicologists realize the need to increase confidence in the scientific validity of novel in vitro methods – especially those being proposed for regulatory application ....

IIVS Co-Publishes Article on Ocular Animal Model Alternatives

April 20, 2021
The human eye may be exposed to chemicals through various situations, such as accidental splashing or exposure to chemical particles, vapours or gases. Workers and consumers are usually advised to immediately wash eyes generously with water following exposure....

IIVS to collaborate with RIFM to develop non-animal technologies for respiratory allergy

March 31, 2021
The Institute for In Vitro Sciences (IIVS) and the Research Institute for Fragrance Materials (RIFM) announce a collaboration to develop a non-animal (in vitro) test designed to assess potential respiratory allergens....

China to Exempt Animal Testing for Imported General Cosmetics on May 1

March 4, 2021
IIVS is pleased to see China providing a pathway for the importation of certain cosmetics without #animaltesting. The pathway does contain certain requirements that the international community must strive to meet - but it is certainly a major step forward. IIVS will continue its outreach with China's National Institute for Food and Drug Control (NIFDC), as well as with provincial FDA's, to continue to implement #nonanimal methods into their regulatory guidelines. Thank you to all our great contributors who fund this important work!...

Acute Electronic Vapour Product Whole Aerosol Exposure of 3D Human Bronchial Tissue

March 2, 2021
IIVS is excited to have taken part in a new publication highlighting the use of non-animal methods to compare cellular and molecular responses of tobacco smoke and Electronic Vapor Product aerosols. Read and Download the open access article here....