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Eye Irritation Testing and Beyond

May 18, 2022
If you missed the webinar: Establishing Scientific Confidence in New Approach Methodologies (NAMs): Eye Irritation Testing and Beyond, co-sponsored by the Risk Assessment and In Vitro and Alternative Methods Specialty Sections of SOT, a recording is now posted. Speakers included Hans Raabe (IIVS) and Dr. Amy Clippinger, (PETA International Science Consortium e.V.)....

IIVS Posters at SOT 2022

April 14, 2022
Thank you to all who visited our booth or poster sessions at the 2022 Society of Toxicology annual meeting. If you would like copies of any of the poster presented we now have them available to view online: Compatibility Determination of Alternative Solvents in the human Cell Line Activation Test (h-CLAT) for the Assessment of Skin Sensitization Cryopreservation of Human Precision-Cut Lung Slices Provides an Immune Competent, Pulmonary Test System for “On-Demand” Use Modification in Procedure of the Reconstructed Human EpiDermis (RhE) Phototoxicity Assay Improving...

Evaluating the Use of Predictive Models in Combination with In Vitro Assays

April 11, 2022
IIVS is excited to announce the publication of 2 papers evaluating the use of predictive models in combination with in vitro assays to provide a quantitative assessment of skin sensitization potential. This work is presented Drs. Frank Gerberick (GF3 Consultancy, Chief Scientific Advisor to IIVS) and Andreas Natsch (Senior Research Fellow at Givaudan ) Integrated Skin Sensitization Assessment Based on OECD Methods (I): Deriving a Point of Departure for Risk Assessment Integrated Skin Sensitization Assessment Based on OECD Methods(II): Hazard and Potency...

Use of alternative test methods in a tiered testing approach to address photoirritation potential of fragrance materials

January 3, 2022
Happy New Year! IIVS is pleased to greet 2022 with the announcement of a joint publication with the Research Institute for Fragrance Materials (RIFM) involving the evaluation of photoirritation potential of over 100 compounds. This effort, spanning the course of 7 years, involved a tiered testing approach with the application of 3 OECD test guidelines: TG 101, 432 and the recently accepted 498, which codifies the acceptance of Reconstructed human Epidermis as a model for assessing this endpoint. Read the full...

IIVS e-News – December 2021

December 9, 2021
In addition to IIVS’ non-animal safety testing services, we also provide efficacy testing designed to evaluate raw materials and formulations for anti-inflammatory and skin tone modulating properties. Inflammation is a common effect experienced after encounters with irritating substances, bacterial infection or by those suffering from auto-immune diseases....

IIVS e-News – September 2021

September 16, 2021
It’s been a very exciting year in the field of New Approach Methodologies (NAMs) with the release of the OECD 497 and 498 Test Guidelines which have codified Defined Approaches for Skin Sensitization and the Reconstructed Human Epidermis Phototoxicity Test, respectively....

Participation at the 2021 Annual Meeting of the American Society for Cellular and Computational Toxicology is Complimentary This Year!

August 2, 2021
As we are once again meeting online, we are pleased to announce that access to the 2021 meeting will be FREE for all attendees. However, if you are interested in helping further ASCCT’s activities, please consider becoming a member—one-year memberships for students are only $20 USD, and individual memberships are $50 USD. By joining as a member, you will have early-bird access to register for our monthly webinars, as well as receive exclusive industry-specific job postings and other relevant opportunities shared...

IIVS e-News – July 2021

June 30, 2021
The Defined Approaches (DAs) to Skin Sensitization Test Guideline cites 2 strategies which can be used to evaluate hazard potential of compounds and 1 strategy to evaluate GHS potency. The hazard DAs involve in vitroapproaches to the evaluation of sensitization using multiple assays which evaluate different steps in the Adverse Outcome Pathway. Both the "2 out of 3" (Fig 1) and "Key Event 3/1" approaches (Fig 2) have been included in the OECD Test Guideline. The potency assessment is an...

IIVS e-News – May 2021

May 6, 2021
IIVS and the Research Institute for Fragrance Materials (RIFM) have initiated a collaboration to develop tests designed to assess potential respiratory allergens. Developing a reliable, in vitroassay to assess the allergenicity of materials to the airway tract has been an area of active research for well over a decade, however most efforts have resulted in poor accuracy and the inability to distinguish airway sensitizers from irritants. By combining the extensive expertise and knowledge base in the field of respiratory toxicology...