Results
How the Good In Vitro Method Practices Guidance Document Can Help Implement New Toxicological Approaches: A Case Study in China
October 17, 2018 Poster/PresentationCurrently China is striving to adopt and implement non-animal, including in vitro, testing approaches for the safety assessment of cosmetics…
Evaluation of Phototoxicity of Ocular Medical and Combination Devices
March 28, 2018 Poster/PresentationTo address ocular device induced phototoxicity, an in vitro 3T3 Neutral Red Uptake Phototoxicity test (OECD 432) for chemicals has…
The Assessment of Phototoxicity Using the 3T3 Neutral Red Uptake (NRU) Phototoxicity Assay and a Modified Photo-Direct Peptide Reactivity Assay (DPRA)
March 28, 2018 Poster/PresentationAlternative methods, including the validated 3T3 Neutral Red Uptake (NRU) Phototoxicity assay (OECD TG 432) may be used as a…
Human In Vitro Models for Respiratory Toxicology: Evaluation of Goblet Cell Hyperplasia, Mucus Production, and Ciliary Beating Assays
March 28, 2018 Poster/PresentationRobust non-animal models and assays for pulmonary toxicology are required to make competent product development and risk assessments for new…
Use of Ex Vivo Precision-Cut Lung Slices as a Screening Tool for Potential Respiratory Toxicity of E-Liquids
March 28, 2018 Poster/PresentationE-vapor product liquids contain a variety of ingredient combinations that should be assessed for human risk. One human lung-relevant testing…
Oral Irritation Assessment of Electronic Liquids Using an In Vitro Oral Testing Model
March 28, 2018 Poster/PresentationWhile data are still being collected and analyzed, there were at least 1,300 accidental electronic liquid (e-liquid) exposures reported as…
Nicotine Characterization of an In Vitro Inhalation Exposure System Using Conventional and Next-Generation Tobacco Products: A US/UK Inter-Laboratory Comparison
March 28, 2018 Poster/PresentationThe US-FDA has regulatory authority over tobacco products, including conventional cigarettes and next generation products (NGPs) such as e-cigarettes and…
Quality Considerations: Redefining Test Systems from Animals to Tissues and Beyond
August 28, 2017 Poster/PresentationThe use of non-whole animal test methods transforms the way regulatory requirements are applied in preclinical testing. Recent global regulatory…
Introducing the 3R Concepts into Pre-College Classrooms
August 28, 2017 Poster/PresentationThis poster provides a snapshot of pre-college teachers (46) within the U.S.—gauging their knowledge and familiarity of the 3Rs and…
Non-Animal Testing Approach to Address Biocompatibility Testing of Medical Devices Required by the United States Food and Drug Administration (US FDA)
August 28, 2017 Poster/PresentationPresented at the 2017 World Congress on Alternatives and Animals in the Life Sciences (WC10) E. Hill, R. Curren, and G.-E.…
Using In Vitro Assays, the Direct Peptide Reactivity Assay (DPRA), KeratinoSens™ Assay (KS), and Human Cell Line Activation Test (h-CLAT) to Assess Skin Sensitization Potential of Electronic Cigarette Liquids
April 4, 2017 Poster/PresentationThree regulatory accepted in vitro assays were evaluated in a proof-of-concept project to determine skin sensitization potential of electronic cigarette…
Precision Digital Dispensing of Patterned Picoliter Quantities of Test Material onto Apical Surfaces of Human 3D-Reconstructed Airway Tissues
March 30, 2017 Poster/PresentationThere is an increasing need for researchers to understand the dynamic aspects of inhaled tobacco product exposure. Available 3D human…