Newsletters
IIVS News and Updates June 2022
July 1, 2022NEW! Good In Vitro Method Practices (GIVMP) Certification IIVS is pleased to announce our new business-to-business GIVIMP Certification Program created to help laboratories: As an OECD guidance document, GIVIMP sets forth internationally recognized quality standards to help ensure that new in vitro methods are ready for implementation, and to foster confidence in the resulting data for use by industry or regulatory bodies.
IIVS e-News – December 2021
December 9, 2021In addition to IIVS’ non-animal safety testing services, we also provide efficacy testing designed to evaluate raw materials and formulations for anti-inflammatory and skin tone modulating properties. Inflammation is a common effect experienced after encounters with irritating substances, bacterial infection or by those suffering from auto-immune diseases.
IIVS e-News – September 2021
September 16, 2021It’s been a very exciting year in the field of New Approach Methodologies (NAMs) with the release of the OECD 497 and 498 Test Guidelines which have codified Defined Approaches for Skin Sensitization and the Reconstructed Human Epidermis Phototoxicity Test, respectively.
IIVS e-News – July 2021
June 30, 2021The Defined Approaches (DAs) to Skin Sensitization Test Guideline cites 2 strategies which can be used to evaluate hazard potential of compounds and 1 strategy to evaluate GHS potency. The hazard DAs involve in vitroapproaches to the evaluation of sensitization using multiple assays which evaluate different steps in the Adverse Outcome Pathway. Both the "2 out of 3" (Fig 1) and "Key Event 3/1" approaches (Fig 2) have been included in the OECD Test Guideline. The potency assessment is an extension of the Kao Integrated Testing Strategy and, in addition to the performance of the DPRA and h-CLAT assays, includes the additional step of QSAR analysis of the compound of interest. (Fig 3). This approach permits classification of sensitizers as strong (GHS 1A), weak (GHS 1B) or non-classified.
IIVS e-News – May 2021
May 6, 2021IIVS and the Research Institute for Fragrance Materials (RIFM) have initiated a collaboration to develop tests designed to assess potential respiratory allergens. Developing a reliable, in vitroassay to assess the allergenicity of materials to the airway tract has been an area of active research for well over a decade, however most efforts have resulted in poor accuracy and the inability to distinguish airway sensitizers from irritants. By combining the extensive expertise and knowledge base in the field of respiratory toxicology of both organizations, we are confident that an assay can be developed to robustly assess this endpoint.
IIVS e-News – October 2020
September 28, 2020IIVS is pleased to announce that Allison Hilberer will participate in the OECD Test Guidelines Programme Expert Groups (OECD TG EG) for eye and skin irritation, phototoxicity and skin sensitization. Allison is a Toxicologist II and Study Director at IIVS where she oversees the conduct of in vitrostudies in these areas. Allison has also been involved in many validation programs and participated in efforts to draft and revise OECD Test Guidelines. Read Post
IIVS e-News – October 2018
October 11, 2018In this issue, learn about our appointment to a working group in China for alternatives, our collaboration with BASF and Givaudan, our presence at estiv2018 and the PCPC 2018 Science Symposium, and more. Read issue.
IIVS e-News – June 2018
June 26, 2018In this issue, find out the dates for the 2019 Practical Methods Workshop and the PISC award for young scientists, learn about upcoming In Vitro-related meetings and extended deadlines for abstract submission, read recent IIVS publications, and more. Read issue.
IIVS eNews – March 2018
March 11, 2018Read the latest issue of our e-newsletter for information about our events and posters at the 2018 Society of Toxicology (SOT) Annual Meeting, presentations at upcoming meetings and more. View issue.
IIVS e-News – January 2018
February 1, 2018Featured in this issue is an article on how an integrated approach to skin sensitization testing can work for your testing program. a preview of IIVS events and posters at SOT, our recent collaboration with BASF to distribute the LuSens test in China, and more. Read issue.