IIVS e-News – July 2021

June 30, 2021

The Defined Approaches (DAs) to Skin Sensitization Test Guideline cites 2 strategies which can be used to evaluate hazard potential of compounds and 1 strategy to evaluate GHS potency. The hazard DAs involve in vitroapproaches to the evaluation of sensitization using multiple assays which evaluate different steps in the Adverse Outcome Pathway. Both the "2 out of 3" (Fig 1) and "Key Event 3/1" approaches (Fig 2) have been included in the OECD Test Guideline. The potency assessment is an extension of the Kao Integrated Testing Strategy and, in addition to the performance of the DPRA and h-CLAT assays, includes the additional step of QSAR analysis of the compound of interest. (Fig 3). This approach permits classification of sensitizers as strong (GHS 1A), weak (GHS 1B) or non-classified.

IIVS e-News – May 2021

May 6, 2021

IIVS and the Research Institute for Fragrance Materials (RIFM) have initiated a collaboration to develop tests designed to assess potential respiratory allergens. Developing a reliable, in vitroassay to assess the allergenicity of materials to the airway tract has been an area of active research for well over a decade, however most efforts have resulted in poor accuracy and the inability to distinguish airway sensitizers from irritants. By combining the extensive expertise and knowledge base in the field of respiratory toxicology of both organizations, we are confident that an assay can be developed to robustly assess this endpoint.

IIVS e-News – October 2020

September 28, 2020

IIVS is pleased to announce that Allison Hilberer will participate in the OECD Test Guidelines Programme Expert Groups (OECD TG EG) for eye and skin irritation, phototoxicity and skin sensitization. Allison is a Toxicologist II and Study Director at IIVS where she oversees the conduct of in vitrostudies in these areas. Allison has also been involved in many validation programs and participated in efforts to draft and revise OECD Test Guidelines. Read Post

IIVS e-News – October 2018

October 11, 2018

In this issue, learn about our appointment to a working group in China for alternatives, our collaboration with BASF and Givaudan, our presence at estiv2018 and the PCPC 2018 Science Symposium, and more.  Read issue.

IIVS e-News – June 2018

June 26, 2018

In this issue, find out the dates for the 2019 Practical Methods Workshop and the PISC award for young scientists, learn about upcoming In Vitro-related meetings and extended deadlines for abstract submission, read recent IIVS publications, and more.  Read issue.

IIVS eNews – March 2018

March 11, 2018

Read the latest issue of our e-newsletter for information about our events and posters at the 2018 Society of Toxicology (SOT) Annual Meeting, presentations at upcoming meetings and more.  View issue.

IIVS e-News – January 2018

February 1, 2018

Featured in this issue is an article on how an integrated approach to skin sensitization testing can work for your testing program. a preview of IIVS events and posters at SOT, our recent collaboration with BASF to distribute the LuSens test in China, and more.  Read issue.

IIVS eNews – October 2017

October 25, 2017

Read the latest issue of our e-newsletter for an update on our work in China and Brazil, our Practical Methods Workshop, and more.  View issue.