September 13, 2019
While the skin sensitization hazard of substances can readily be identified using non-animal methods, the classification of potency into UN GHS sub-categories 1A and 1B remains challenging. The kinetic direct peptide reactivity assay (kDPRA) is a modification of the DPRA (OECD TG 442C) wherein the reaction kinetics of a test substance towards a synthetic cysteine-containing peptide is evaluated. For this purpose, several concentrations of the test substance are incubated with the synthetic peptide for several incubation times at 25°C. After...
kDPRA | Agro/Petrochemical | Cleaning Products | Fragrance & Flavors | Household & Consumer Products | Andreas Natsch | Barbara Birk | Britta Wareing | Cindy Ryan | Erin Hill
May 9, 2019
Gaithersburg, MD – May 8, 2019 – The Institute for In Vitro Sciences, Inc. (IIVS) has received a grant from the European Partnership for Alternative Approaches to Animal Testing (EPAA) to support its annual training of Chinese scientists in non-animal testing methods. As part of the agreement, two scientists from BASF SE, a member of EPAA, will join IIVS to provide hands-on training in China for four non-animal approaches for skin sensitization. This training follows the recent announcement by China’s...
DPRA | Short Time Exposure | Cosmetic & Personal Care | Alternative testing in China | Alternative Testing Methods | BASF SE | China | DPRA | EPAA | Erin Hill
April 3, 2019
Gaithersburg, MD – April 3, 2019 – The Institute for In Vitro Sciences (IIVS) applauds China’s National Medical Products Administration (NMPA) for their acceptance of certain non-animal (alternative) test methods for the regulation of cosmetics. In a notice issued on March 22, the NMPA drafted acceptance of nine test methods including:
Direct Peptide Reaction Assay (DPRA) for Skin Sensitization (OECD TG 442C)
Short Time Exposure Assay (STE) for eye irritation (OECD TG 491)
These new regulations will go into effect January...
DPRA | Short Time Exposure | Cosmetic & Personal Care | Alternative testing in China | Alternative Testing Methods | China | Erin Hill | NIFDC | NMPA | OECD TG 442C
March 22, 2019
We are pleased to share that today China’s National Medical Products Association (NMPA) has approved new methods for the regulations of cosmetics. Among these are two in vitro methods: DPRA for skin sensitization and the Short Time Exposure (STE) assay for eye irritation. IIVS’ International Outreach Program introduced these methods during its training program with NMPA and we will continue to support their implementation in key laboratories....
DPRA | Short Time Exposure | Cosmetic & Personal Care | Alternative Testing Methods | China
February 21, 2019
Measures outlined in the Industrial Chemicals Bill 2017, passed by the Australian senate on 19 February, 2019, will apply to both imported and Australian produced chemicals for use as cosmetic ingredients. The commencement date is set for July 2020 although it is believed that the cosmetics industry will not need an entire year to implement changes to comply with the new law. Additionally, the bill includes funding for the development of alternative test methods.
Read the full article....
BCOP | Ocular Screening | Sensitization | Skin Irritation Test | Skin Sensitization | Cosmetic & Personal Care | Fragrance & Flavors | non-animal testing
October 17, 2018
By Amanda Lim, Editor (Singapore) CosmeticsDesign-Asia.com
Although China has made significant strides in moving away from animal testing, its challenges suggest it may take more than five years for the country to completely stop compulsory animal-testing for cosmetics, says Hedy He, regulatory analyst and editor of ChemLinked: "In the short term a total ban on animal testing is unlikely given the lack of testing infrastructure and technical capacity shortcomings of the industry."
The Overarching Issue
Among the many obstacles, the overarching one is the...
3T3 Neutral Red Uptake | BCOP | Phototoxicity | Sensitization | Cosmetic & Personal Care | alternatives to animal testing | China | Education & Outreach | skin sensitization
August 28, 2018
GAITHERSBURG, MD –August 28– The Institute for In Vitro Sciences (IIVS), with an established track record in the validation of alternatives to animal testing, is teaming up with BASF and Givaudan to validate an improved skin sensitization reactivity method to address the needs of toxicologists and regulators.
Scientists at BASF and Givaudan have developed the Kinetic Direct Peptide Reactivity Assay (Kinetic DPRA), a non-animal test to predict allergic reactions in the skin known as sensitization. Three other non-animal sensitizer tests have...
Sensitization | Andreas Natsch | Assay Validation | BASF SE | Erin Hill | Givaudan | kDPRA | Kinetic Direct Peptide Reactivity Assay | Kinetic DPRA | non-animal testing