Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS | Industries Fragrance & Flavors
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Archive

IIVS Posters at Eurotox 2019

September 13, 2019
Eurotox 2019 September 8-11, 2019 Helsinki, Finland Thank you to all who visited us at Eurotox 2019! Respiratory Toxicology: Increased Throughput and Cryopreservation of Precision-cut Lung Slices Extend the Utility of Human-relevant, 3-Dimensional Pulmonary Test Systems Skin Sensitization: The kinetic Direct Peptide Reactivity Assay (kDPRA): An in chemico Method to Characterize the Skin Sensitization Potency of Chemicals eLearning to Promote Use of Alternatives: Promoting the Uptake of Alternatives to Animal Testing Through the Development of eLearning Tools ...

kDPRA: An in chemico Method to Characterize the Skin Sensitization Potency of Chemicals

September 13, 2019
While the skin sensitization hazard of substances can readily be identified using non-animal methods, the classification of potency into UN GHS sub-categories 1A and 1B remains challenging. The kinetic direct peptide reactivity assay (kDPRA) is a modification of the DPRA (OECD TG 442C) wherein the reaction kinetics of a test substance towards a synthetic cysteine-containing peptide is evaluated. For this purpose, several concentrations of the test substance are incubated with the synthetic peptide for several incubation times at 25°C. After...

See You at EUROTOX 2019!

August 15, 2019
  IIVS is excited about meeting attendees of the 55th EUROTOX conference! Please join us at booth #34 to meet our representatives who are looking forward to discussing trends and New Methodologies in Alternative Approaches (NAMs) to toxicological research, as well providing updates on services offered by our organization! Also, don’t miss our posters: The kinetic Direct Peptide Reactivity Assay (kDPRA): An in chemico method to characterize the skin sensitization potency of chemicals (Poster Viewing 1) Increased Throughput and Cryopreservation of Precision-Cut Lung...

IIVS Posters at SOT 2019

March 18, 2019
Society of Toxicology 58th Annual Meeting March 10-14, 2019 Baltimore, MD Thank you to all who visited us at the 2019 SOT meeting! Respiratory Toxicology: Development of a Method to Measure Cigarette, e-Cigarette and Tobacco Heating Product Skin Staining Increased Throughput and Cryopreservation of Precision-cut Lung Slices Extend the Utility of Human-relevant, 3-Dimensional Pulmonary Test Systems Good In Vitro Method Practices: Shipping Study to Evaluate the Performance of the Labcyte Epi-Model 24 Tissues for Use in the Skin Irritation Test (OECD Test Guideline 439) after...

Australian Bill Passed to End Animal Testing for Cosmetics

February 21, 2019
Measures outlined in the Industrial Chemicals Bill 2017, passed by the Australian senate on 19 February, 2019, will apply to both imported and Australian produced chemicals for use as cosmetic ingredients. The commencement date is set for July 2020 although it is believed that the cosmetics industry will not need an entire year to implement changes to comply with the new law. Additionally, the bill includes funding for the development of alternative test methods. Read the full article....

Video: The 3T3 Neutral Red Uptake Phototoxicity Test

October 31, 2018
This training video explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light.  The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer:  Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to video production reasons,...

ARE-Nrf2 Luciferase Keratinocyte Activation Test Method (OECD 442D)

October 18, 2018
KeratinoSensTM and LuSens are cell-based reporter gene assays that model the second key event in the Adverse Outcome Pathway for Dermal Sensitization, namely keratinocyte activation.  The assays measure the induction of a stably transfected luciferase gene under the control of the antioxidant response element (ARE) derived from the human AKR1C2 or rat NQO1 gene. The results of these assays can be used in a Weight of Evidence approach as an alternative to animal testing methods for the purpose of hazard identification. IIVS has...

Encouraging Regulatory Acceptance of Non-Animal Testing Methods Discussed at Annual SACATM Meeting

October 2, 2018
Among the topics discussed at the annual Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) meeting held in early September was ways to encourage both regulators and regulated industry to use new approach methodologies (NAMs). The meeting brought together experts from academia, industry, and animal welfare organizations and the importance of collaboration among the different groups and geographical regions was a recurring theme. Learn more...

Abstract Deadline Extended for EUSAAT 2018

June 21, 2018
The 21st European Congress on Alternatives to Animal Testing & 18th Annual Congress of EUSAAT (European Society for Alternatives to Animal Testing) will take place in Linz, Austria, 23-26 September.  Submission deadlines for both oral and poster presentations have been extended to July 6. Erin Hill and Rodger Curren from IIVS are both speaking at the event. Learn more about the meeting, including the scientific program, invited speakers, and how to register.  ...

Abstract Deadline Extended for ESTIV 2018

June 18, 2018
The 20th International Congress on In Vitro Toxicology (ESTIV2018) happening in Berlin, 15-18 October, has extended their abstract submission deadline to July 1.  Several grants and bursaries are also still open to applicants until July 1, including the PETA International Science Consortium early-career scientist award. Learn more about the meeting, including the scientific program, invited speakers, and how to register.  ...