September 13, 2019
While the skin sensitization hazard of substances can readily be identified using non-animal methods, the classification of potency into UN GHS sub-categories 1A and 1B remains challenging. The kinetic direct peptide reactivity assay (kDPRA) is a modification of the DPRA (OECD TG 442C) wherein the reaction kinetics of a test substance towards a synthetic cysteine-containing peptide is evaluated. For this purpose, several concentrations of the test substance are incubated with the synthetic peptide for several incubation times at 25°C. After...
kDPRA | Agro/Petrochemical | Cleaning Products | Fragrance & Flavors | Household & Consumer Products | Andreas Natsch | Barbara Birk | Britta Wareing | Cindy Ryan | Erin Hill
August 28, 2018
GAITHERSBURG, MD –August 28– The Institute for In Vitro Sciences (IIVS), with an established track record in the validation of alternatives to animal testing, is teaming up with BASF and Givaudan to validate an improved skin sensitization reactivity method to address the needs of toxicologists and regulators.
Scientists at BASF and Givaudan have developed the Kinetic Direct Peptide Reactivity Assay (Kinetic DPRA), a non-animal test to predict allergic reactions in the skin known as sensitization. Three other non-animal sensitizer tests have...
Sensitization | Andreas Natsch | Assay Validation | BASF SE | Erin Hill | Givaudan | kDPRA | Kinetic Direct Peptide Reactivity Assay | Kinetic DPRA | non-animal testing