Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS | Industries Agro/Petrochemical
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Archive

IIVS Posters at SOT 2019

March 18, 2019
Society of Toxicology 58th Annual Meeting March 10-14, 2019 Baltimore, MD Thank you to all who visited us at the 2019 SOT meeting! Respiratory Toxicology: Development of a Method to Measure Cigarette, e-Cigarette and Tobacco Heating Product Skin Staining Increased Throughput and Cryopreservation of Precision-cut Lung Slices Extend the Utility of Human-relevant, 3-Dimensional Pulmonary Test Systems Good In Vitro Method Practices: Shipping Study to Evaluate the Performance of the Labcyte Epi-Model 24 Tissues for Use in the Skin Irritation Test (OECD Test Guideline 439) after...

Increased Throughput and Cryopreservation of Precision-cut Lung Slices Extend the Utility of Human-relevant, 3-Dimensional Pulmonary Test Systems

March 18, 2019
Human-relevant, in vitro/ex vivo assays are considered an ethical and economically viable manner by which to screen the thousands of chemicals requiring hazard assessment. Of the 3-dimensional models, human precision-cut lung slices (PCLS) are often considered the most physiologically relevant pulmonary test system, but lower throughput and difficulties in cryopreservation have hampered PCLS use. We have modified a tissue slicer to accommodate 3 tissue cores for simultaneous slicing. Increased slice production was quantified using agarose and tissue cores in the slicer....

Register For ICCVAM’s Free Webinar on In Vitro Inhalation Toxicity Testing

January 10, 2019
NICEATM will organize a free webinar on behalf of ICCVAM on January 22, 2019 between 1:00-2:30 p.m. Eastern Time.  Registration will be required. Topics will include an overview of ongoing collaborative efforts, as well as the presentation of a case study on refining inhalation risk assessment for point of contact toxicity that uses a source-to-outcome approach with both in vitro and in silico methods. The preliminary agenda and additional information about presentations will be posted when available....

ARE-Nrf2 Luciferase Keratinocyte Activation Test Method (OECD 442D)

October 18, 2018
KeratinoSensTM and LuSens are cell-based reporter gene assays that model the second key event in the Adverse Outcome Pathway for Dermal Sensitization, namely keratinocyte activation.  The assays measure the induction of a stably transfected luciferase gene under the control of the antioxidant response element (ARE) derived from the human AKR1C2 or rat NQO1 gene. The results of these assays can be used in a Weight of Evidence approach as an alternative to animal testing methods for the purpose of hazard identification. IIVS has...

IIVS Hosts Quarterly Meeting for SQA’s Computer Validation and IT Compliance (CVIC) Specialty Section

October 4, 2018
The CVIC agenda included a presentation and follow-up discussion on artificial intelligence and computer learning and their use in regulated industry, a panel discussion of cloud computing adoption in “GxP” environments, and open discussion on the use of the “Internet of Things” and data integrity and governance concepts.  In addition to the CVIC member, an FDA representative was on site to gather industry input on specific topics.  IIVS is pleased to support activities like this through the Society of Quality Assurance. If...

Encouraging Regulatory Acceptance of Non-Animal Testing Methods Discussed at Annual SACATM Meeting

October 2, 2018
Among the topics discussed at the annual Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) meeting held in early September was ways to encourage both regulators and regulated industry to use new approach methodologies (NAMs). The meeting brought together experts from academia, industry, and animal welfare organizations and the importance of collaboration among the different groups and geographical regions was a recurring theme. Learn more...

Strategies for Eye Irritation Testing

September 17, 2018
Determination of ocular irritation potential is a key toxicological endpoint required to support chemical and raw material characterization and industrial hygiene, to guide product development, and to achieve final product safety standards.  IIVS possesses extensive experience with numerous test methods and testing strategies for commercial, industrial and regulatory applications.  From standard regulatory hazard assessments to providing information on the degree of ocular irritation, to discriminating among extremely mild eye area products, IIVS’ Study Directors take the time to understand your...

Registration Now Open for Practical Methods 2019

August 27, 2018
IIVS is excited to announce that registration is now open for our 2019 Practical Methods for In Vitro Toxicology Workshop. Space is limited so please book as soon as possible to guarantee your spot. ...

Modernization of EPA “6-Pack” of Acute Toxicity Tests Continues

July 27, 2018
The US Environmental Protection Agency (US EPA) continues to drive significant efforts in the United States to modernize the battery of acute toxicity tests classically known as the “6-pack.” Learn More....

Modernization of EPA “6-Pack” of Acute Toxicity Tests Continues

July 26, 2018
The US Environmental Protection Agency (US EPA) continues to drive significant efforts in the United States to modernize the battery of acute toxicity tests classically known as the “6-pack.” Known for many years as an “all in vivo” testing strategy for products registered under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), the 6-pack was revised in 2015 to include non-animal (in vitro/ex vivo) test methods for classification and labeling for Eye Irritation, both for commonly used household cleaning products...