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Available Endpoints
Cytotoxicity
Viability
Oxidative Stress
Mitotoxicity
Goblet Cell Hyperplasia
Tight Junction Integrity
Functional Biomarkers
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Respiratory Toxicology | Agro/Petrochemical | Specialty Chemical | Tobacco
October 18, 2019The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to identify, discuss and develop recommendations for optimal scientific/technical approaches for utilizing in vitro assay data within and across tobacco and nicotine product categories. Workshops provide a unique opportunity for invited expert stakeholders to share experiences and to develop recommendations that may serve as a resource for developing optimal approaches and data to evaluate the toxicity of tobacco and nicotine products. It is envisioned that some of...
Respiratory Toxicology | Tobacco | NGTP | P. Desai | R. Curren
October 17, 2019The Family Smoking Prevention and Tobacco Control Act gave the FDA regulatory authority over next generation tobacco products (NGTP) such as E-vapor products. E-vapor product liquids contain a variety of ingredient combinations that should be assessed for human risk. One human lung-relevant testing platform with reasonable throughput, is human precision-cut lung slices (HuPCLS). HuPCLS are arguably the most complex non-animal model of the lung, retaining native architecture and immune-competent cells over multi-week culture periods. HuPCLS were exposed to three concentrations...
Precision Cut Lung Slices (PCLS) | Respiratory Toxicology | Tobacco | Hans Raabe | Holger Behrsing | HuPCLS | New Generation Tobacco Products | NGTP