Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS | Industries Household & Consumer Products
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Archive

IIVS Posters at Eurotox 2019

September 13, 2019
Eurotox 2019 September 8-11, 2019 Helsinki, Finland Thank you to all who visited us at Eurotox 2019! Respiratory Toxicology: Increased Throughput and Cryopreservation of Precision-cut Lung Slices Extend the Utility of Human-relevant, 3-Dimensional Pulmonary Test Systems Skin Sensitization: The kinetic Direct Peptide Reactivity Assay (kDPRA): An in chemico Method to Characterize the Skin Sensitization Potency of Chemicals eLearning to Promote Use of Alternatives: Promoting the Uptake of Alternatives to Animal Testing Through the Development of eLearning Tools ...

kDPRA: An in chemico Method to Characterize the Skin Sensitization Potency of Chemicals

September 13, 2019
While the skin sensitization hazard of substances can readily be identified using non-animal methods, the classification of potency into UN GHS sub-categories 1A and 1B remains challenging. The kinetic direct peptide reactivity assay (kDPRA) is a modification of the DPRA (OECD TG 442C) wherein the reaction kinetics of a test substance towards a synthetic cysteine-containing peptide is evaluated. For this purpose, several concentrations of the test substance are incubated with the synthetic peptide for several incubation times at 25°C. After...

See You at EUROTOX 2019!

August 15, 2019
  IIVS is excited about meeting attendees of the 55th EUROTOX conference! Please join us at booth #34 to meet our representatives who are looking forward to discussing trends and New Methodologies in Alternative Approaches (NAMs) to toxicological research, as well providing updates on services offered by our organization! Also, don’t miss our posters: The kinetic Direct Peptide Reactivity Assay (kDPRA): An in chemico method to characterize the skin sensitization potency of chemicals (Poster Viewing 1) Increased Throughput and Cryopreservation of Precision-Cut Lung...

IIVS Posters at SOT 2019

March 18, 2019
Society of Toxicology 58th Annual Meeting March 10-14, 2019 Baltimore, MD Thank you to all who visited us at the 2019 SOT meeting! Respiratory Toxicology: Development of a Method to Measure Cigarette, e-Cigarette and Tobacco Heating Product Skin Staining Increased Throughput and Cryopreservation of Precision-cut Lung Slices Extend the Utility of Human-relevant, 3-Dimensional Pulmonary Test Systems Good In Vitro Method Practices: Shipping Study to Evaluate the Performance of the Labcyte Epi-Model 24 Tissues for Use in the Skin Irritation Test (OECD Test Guideline 439) after...

Shipping Study to Evaluate the Performance of the LabCyte EPI-MODEL 24 Tissues for Use in the Skin Irritation Test (OECD TG 439) After Long-Haul Airfreight

March 18, 2019
It is recommended that an evaluation of the impact of shipping of Reconstructed human Epidermis (RhE) tissues be conducted especially after long-haul airfreight shipments. The OECD Test Guideline 439 (OECD TG 439), In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method, recommends that users do so by verifying the barrier properties of the tissues after receipt. In this study, LabCyte EPI-MODEL 24 tissues were received in the USA after an overnight shipment from Japan and were tested to evaluate their performance...

Increased Throughput and Cryopreservation of Precision-cut Lung Slices Extend the Utility of Human-relevant, 3-Dimensional Pulmonary Test Systems

March 18, 2019
Human-relevant, in vitro/ex vivo assays are considered an ethical and economically viable manner by which to screen the thousands of chemicals requiring hazard assessment. Of the 3-dimensional models, human precision-cut lung slices (PCLS) are often considered the most physiologically relevant pulmonary test system, but lower throughput and difficulties in cryopreservation have hampered PCLS use. We have modified a tissue slicer to accommodate 3 tissue cores for simultaneous slicing. Increased slice production was quantified using agarose and tissue cores in the slicer....

Register For ICCVAM’s Free Webinar on In Vitro Inhalation Toxicity Testing

January 10, 2019
NICEATM will organize a free webinar on behalf of ICCVAM on January 22, 2019 between 1:00-2:30 p.m. Eastern Time.  Registration will be required. Topics will include an overview of ongoing collaborative efforts, as well as the presentation of a case study on refining inhalation risk assessment for point of contact toxicity that uses a source-to-outcome approach with both in vitro and in silico methods. The preliminary agenda and additional information about presentations will be posted when available....

ARE-Nrf2 Luciferase Keratinocyte Activation Test Method (OECD 442D)

October 18, 2018
KeratinoSensTM and LuSens are cell-based reporter gene assays that model the second key event in the Adverse Outcome Pathway for Dermal Sensitization, namely keratinocyte activation.  The assays measure the induction of a stably transfected luciferase gene under the control of the antioxidant response element (ARE) derived from the human AKR1C2 or rat NQO1 gene. The results of these assays can be used in a Weight of Evidence approach as an alternative to animal testing methods for the purpose of hazard identification. IIVS has...

Encouraging Regulatory Acceptance of Non-Animal Testing Methods Discussed at Annual SACATM Meeting

October 2, 2018
Among the topics discussed at the annual Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) meeting held in early September was ways to encourage both regulators and regulated industry to use new approach methodologies (NAMs). The meeting brought together experts from academia, industry, and animal welfare organizations and the importance of collaboration among the different groups and geographical regions was a recurring theme. Learn more...

Strategies for Eye Irritation Testing

September 17, 2018
Determination of ocular irritation potential is a key toxicological endpoint required to support chemical and raw material characterization and industrial hygiene, to guide product development, and to achieve final product safety standards.  IIVS possesses extensive experience with numerous test methods and testing strategies for commercial, industrial and regulatory applications.  From standard regulatory hazard assessments to providing information on the degree of ocular irritation, to discriminating among extremely mild eye area products, IIVS’ Study Directors take the time to understand your...