Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS | Alternative Testing Methods
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Alternative Testing Methods Tag

Creation of Italian Working Group on Alternative Methods

June 18, 2019
The Italian Health Ministry recently announced the creation of a working group for the promotion of alternative methods. Experts on alternative methods, along with stakeholders, will meet monthly and update the health minister every six months. The group has been tasked with a number of responsibilities, including ensuring the proper implementation of the 2013 EU ban on animal testing for cosmetics and the correct use — and adequate funding — of alternative methods. More Information: Centro3R Italian Health Ministry Press Release (in...

European Partnership Supports IIVS Training of Chinese Scientists in Non-animal Tests

May 9, 2019
Gaithersburg, MD – May 8, 2019 – The Institute for In Vitro Sciences, Inc. (IIVS) has received a grant from the European Partnership for Alternative Approaches to Animal Testing (EPAA) to support its annual training of Chinese scientists in non-animal testing methods. As part of the agreement, two scientists from BASF SE, a member of EPAA, will join IIVS to provide hands-on training in China for four non-animal approaches for skin sensitization. This training follows the recent announcement by China’s...

China’s Acceptance of Certain Non-Animal Testing Methods for the Regulation of Cosmetics

April 3, 2019
Gaithersburg, MD – April 3, 2019 – The Institute for In Vitro Sciences (IIVS) applauds China’s National Medical Products Administration (NMPA) for their acceptance of certain non-animal (alternative) test methods for the regulation of cosmetics. In a notice issued on March 22, the NMPA drafted acceptance of nine test methods including: Direct Peptide Reaction Assay (DPRA) for Skin Sensitization (OECD TG 442C) Short Time Exposure Assay (STE) for eye irritation (OECD TG 491) These new regulations will go into effect January...

Illinois’ Senate Bans Sale of Cosmetics Tested on Animals

March 28, 2019
The Illinois state Senate has passed a bill which would amend the state's Food, Drug and Cosmetics Act to include a ban on the sale or import of cosmetics that have been tested on animals. Overall, the bill is in line with the California Act which is currently the most stringent law within the U.S. The Illinois bill is now being considered by the state's House of Representatives....

China’s NMPA Approves Two New In Vitro Methods For Regulating Cosmetics

March 22, 2019
We are pleased to share that today China’s National Medical Products Association (NMPA) has approved new methods for the regulations of cosmetics.  Among these are two in vitro methods: DPRA for skin sensitization and the Short Time Exposure (STE) assay for eye irritation. IIVS’ International Outreach Program introduced these methods during its training program with NMPA and we will continue to support their implementation in key laboratories....

Video: The 3T3 Neutral Red Uptake Phototoxicity Test

October 31, 2018
This training video explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light.  The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer:  Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to video production reasons,...

IIVS Appointed to China’s Alternatives Working Group for Cosmetics

October 9, 2018
Gaithersburg, MD – October 9, 2018 – U.S. based Institute for In Vitro Sciences (IIVS) has been invited by China’s National Institute for Food and Drug Control (NIFDC) to join their working group on alternatives for cosmetics.  The newly established group was announced by the NIFDC during their 2nd International Conference on Cosmetics Alternative Methods held in Beijing in September.  Chaired by NIFDC Vice Director, Lu Yong, the working group also includes representatives from several provincial government agencies and companies...

Webinar: Precision-cut Lung Slices

October 5, 2018
Dr. Holger Behrsing, Principal Scientist with IIVS, recently presented "Precision-cut Lung Slices (PCLS)" for the 2018 PETA International Science Consortium webinar series on non-animal inhalation testing methods. ...

The Assessment of Phototoxicity Using the 3T3 Neutral Red Uptake (NRU) Phototoxicity Assay and a Modified Photo-Direct Peptide Reactivity Assay (DPRA)

March 28, 2018
Alternative methods, including the validated 3T3 Neutral Red Uptake (NRU) Phototoxicity assay (OECD TG 432) may be used as a pre-clinical test to address phototoxicity. Currently, there are no validated alternative test methods to identify photoallergens; however, there are several validated alternative test methods to address skin sensitization, including the Direct Peptide Reactivity Assay (DPRA) (OECD 442C). To address photoallergy, we utilized the 3T3 Phototoxicity assay in combination with a modified photo-DPRA assay to determine if these assays were able...

Video: The 3T3 Neutral Red Uptake Phototoxicity Test – Spanish

October 6, 2017
This new training video explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to video production...