March 22, 2019
We are pleased to share that today China’s National Medical Products Association (NMPA) has approved new methods for the regulations of cosmetics. Among these are two in vitro methods: DPRA for skin sensitization and the Short Time Exposure (STE) assay for eye irritation. IIVS’ International Outreach Program introduced these methods during its training program with NMPA and we will continue to support their implementation in key laboratories....
March 18, 2019
Society of Toxicology 58th Annual Meeting
March 10-14, 2019
Thank you to all who visited us at the 2019 SOT meeting!
Development of a Method to Measure Cigarette, e-Cigarette and Tobacco Heating Product Skin Staining
Increased Throughput and Cryopreservation of Precision-cut Lung Slices Extend the Utility of Human-relevant, 3-Dimensional Pulmonary Test Systems
Good In Vitro Method Practices:
Shipping Study to Evaluate the Performance of the Labcyte Epi-Model 24 Tissues for Use in the Skin Irritation Test (OECD Test Guideline 439) after...
March 18, 2019
It is recommended that an evaluation of the impact of shipping of Reconstructed human Epidermis (RhE) tissues be conducted especially after long-haul airfreight shipments. The OECD Test
Guideline 439 (OECD TG 439), In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method, recommends that users do so by verifying the barrier properties of the tissues after receipt. In this study, LabCyte EPI-MODEL 24 tissues were received in the USA after an overnight shipment from Japan and were tested to evaluate their performance...
March 18, 2019
Human-relevant, in vitro/ex vivo assays are considered an ethical and economically viable manner by which to screen the thousands of chemicals requiring hazard assessment. Of the 3-dimensional models, human precision-cut lung slices (PCLS) are often considered the most physiologically relevant pulmonary test system, but lower throughput and difficulties in cryopreservation have hampered PCLS use.
We have modified a tissue slicer to accommodate 3 tissue cores for simultaneous slicing. Increased slice production was quantified using agarose and tissue cores in the slicer....
February 21, 2019
Measures outlined in the Industrial Chemicals Bill 2017, passed by the Australian senate on 19 February, 2019, will apply to both imported and Australian produced chemicals for use as cosmetic ingredients. The commencement date is set for July 2020 although it is believed that the cosmetics industry will not need an entire year to implement changes to comply with the new law. Additionally, the bill includes funding for the development of alternative test methods.
Read the full article....
January 10, 2019
NICEATM will organize a free webinar on behalf of ICCVAM on January 22, 2019 between 1:00-2:30 p.m. Eastern Time. Registration will be required.
Topics will include an overview of ongoing collaborative efforts, as well as the presentation of a case study on refining inhalation risk assessment for point of contact toxicity that uses a source-to-outcome approach with both in vitro and in silico methods.
The preliminary agenda and additional information about presentations will be posted when available....
October 31, 2018
This training video explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors.
Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to video production reasons,...
October 18, 2018
KeratinoSensTM and LuSens are cell-based reporter gene assays that model the second key event in the Adverse Outcome Pathway for Dermal Sensitization, namely keratinocyte activation. The assays measure the induction of a stably transfected luciferase gene under the control of the antioxidant response element (ARE) derived from the human AKR1C2 or rat NQO1 gene.
The results of these assays can be used in a Weight of Evidence approach as an alternative to animal testing methods for the purpose of hazard identification.
October 17, 2018
Currently China is striving to adopt and implement non-animal, including in vitro, testing approaches for the safety assessment of cosmetics and ingredients. Collaborative efforts between industry and the Institute for In Vitro Sciences (IIVS, Gaithersburg, USA) have focused on the transfer of several OECD Test Guideline methods to government laboratories in China and have supported the creation of an in vitro toxicology testing laboratory within the Zhejiang Institute for Food and Drug Control (Hangzhou, China). Recently BASF SE (Ludwigshafen, Germany) and IIVS...
October 17, 2018
By Amanda Lim, Editor (Singapore) CosmeticsDesign-Asia.com
Although China has made significant strides in moving away from animal testing, its challenges suggest it may take more than five years for the country to completely stop compulsory animal-testing for cosmetics, says Hedy He, regulatory analyst and editor of ChemLinked: "In the short term a total ban on animal testing is unlikely given the lack of testing infrastructure and technical capacity shortcomings of the industry."
The Overarching Issue
Among the many obstacles, the overarching one is the...