Archive
Strategies for Eye Irritation Testing
September 17, 2018Determination of ocular irritation potential is a key toxicological endpoint required to support chemical and raw material characterization and industrial hygiene, to guide product development, and to achieve final product safety standards. IIVS possesses extensive experience with numerous test methods and testing strategies for commercial, industrial and regulatory applications. From standard regulatory hazard assessments to providing information on the degree of ocular irritation, to discriminating among extremely mild eye area products, IIVS’ Study Directors take the time to understand your...
Abstract Deadline Extended for EUSAAT 2018
June 21, 2018The 21st European Congress on Alternatives to Animal Testing & 18th Annual Congress of EUSAAT (European Society for Alternatives to Animal Testing) will take place in Linz, Austria, 23-26 September. Submission deadlines for both oral and poster presentations have been extended to July 6. Erin Hill and Rodger Curren from IIVS are both speaking at the event. Learn more about the meeting, including the scientific program, invited speakers, and how to register. ...
Abstract Deadline Extended for ESTIV 2018
June 18, 2018The 20th International Congress on In Vitro Toxicology (ESTIV2018) happening in Berlin, 15-18 October, has extended their abstract submission deadline to July 1. Several grants and bursaries are also still open to applicants until July 1, including the PETA International Science Consortium early-career scientist award. Learn more about the meeting, including the scientific program, invited speakers, and how to register. ...
The Assessment of Phototoxicity Using the 3T3 Neutral Red Uptake (NRU) Phototoxicity Assay and a Modified Photo-Direct Peptide Reactivity Assay (DPRA)
March 28, 2018Alternative methods, including the validated 3T3 Neutral Red Uptake (NRU) Phototoxicity assay (OECD TG 432) may be used as a pre-clinical test to address phototoxicity. Currently, there are no validated alternative test methods to identify photoallergens; however, there are several validated alternative test methods to address skin sensitization, including the Direct Peptide Reactivity Assay (DPRA) (OECD 442C). To address photoallergy, we utilized the 3T3 Phototoxicity assay in combination with a modified photo-DPRA assay to determine if these assays were able...
IIVS and BASF Collaborate to Distribute Test Method to Replace Animal Testing in China
January 9, 2018GAITHERSBURG, MD – January 9, 2018 – The Institute for In Vitro Sciences, Inc. (IIVS) today announced a collaboration with BASF to import a non-animal, cell based, safety test into China. The LuSens test, developed by BASF, is an in vitro test to detect the sensitization potential of chemicals to human skin. The test was developed to be license free and shared with the scientific community at-large. It has recently been incorporated into the Organization for Economic Co-operation and Development...
IIVS in Allure Magazine – President Erin Hill Talks About Non-animal Testing of Cosmetics in China
October 24, 2017IIVS President, Erin Hill, talked to Allure magazine about efforts to phase out animal testing of cosmetics in China and replace the practice with non-animal methods. The article, which appears in the November issue, examines that while animal testing is nearly non-existent in the U.S. and officially banned in the E.U., China’s regulatory agencies require animal testing of imported cosmetics and domestically manufactured ones, with some exceptions. Hill goes on to talk about the collaboration between IIVS and the Chinese...
Video: Bovine Corneal Opacity & Permeability Test – Spanish
October 16, 2017This 13- minute training video demonstrates how to perform the BCOP assay according to the Test Guidelines set forth for the assay by the Organization for Economic Co-operation and Development (OECD TG 437). The video focuses on steps that are critical to the success of the assay such as handling of the isolated cornea and removal of the test material from the cornea at the conclusion of the exposure time. ...
Video: The 3T3 Neutral Red Uptake Phototoxicity Test – Spanish
October 6, 2017This new training video explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to video production...
Quality Considerations: Redefining Test Systems from Animals to Tissues and Beyond
August 28, 2017The use of non-whole animal test methods transforms the way regulatory requirements are applied in preclinical testing. Recent global regulatory initiatives emphasize the importance of transitioning to human relevant assays and test systems that do not use animals. When these methods are moved from research into the regulated arena, GLP principles must be followed. The GLPs were originally written in the 1970s, when the vast majority of regulated research was performed using animals as the test system. Current innovative, alternative...
Collaborative Effort Aims to Replace Rabbit Test for Personal Lubricant Products
August 21, 2017Study in Response to Consumer Demands for Humane Testing Washington, D.C. — August 21, 2017 — A first-of-its kind collaborative project is underway to find a non-animal test method to replace the rabbit vaginal irritation test for personal lubricants. The U.S. Food and Drug Administration (FDA) gave the project a green light as part of the agency’s program aimed at modernizing the tests used to develop and evaluate medical devices. The work of the lubricant industry, the Institute for In Vitro Sciences...