September 13, 2019The US EPA has committed to dramatically reducing animal testing with a commitment for total elimination by the year 2035.
IIVS is proud to have played a part in the move to reduce animal testing, starting with the successful development, and acceptance, of the non-animal eye-irritation defined approach, which was developed by an industry and regulatory consortium led by IIVS' CEO Rodger D. Curren, Ph.D.
IIVS looks forward to continuing its collaboration with stakeholders to help the agency achieve its goals.
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BCOP | Eye Irritation Test | Ocular Screening
August 24, 2016The Ocular Irritection Assay is an in chemico eye irritation assay that detects, ranks, and predicts the corneal irritation potential of a test material. The assay assesses changes to the reagent solution (containing proteins, glycoproteins, lipids), which mimics the denaturation and disruption that occurs in corneal proteins in vivo.
The test article is applied to a membrane disc that controls the delivery to the reagent solution. The changes in the protein structure are measured by optical density readings in the reagent...
Assessing Corneal Recovery | BCOP | CAMVA | Corneal Recovery Modeling | Eye Irritation Test | NociOcular Eye Sting | Ocular Screening | Short Time Exposure
August 24, 2016The CAMVA is an in vitro assay that measures the presence and degree of vascular effect to the chorioallantoic membrane (CAM) of 10-day fertilized eggs following exposure to test article.
After exposure, the CAM is examined visually for vascular hemorrhaging, capillary injection and/or ghost vessels at the test material application site. The concentration that elicits a positive response in 50% of the treated CAM specimens (RC50) indicates ocular irritation potential of a test material. Exposed CAM can also be evaluated for...
BCOP | CAMVA | Eye Irritation Test | Ocular | Ocular Screening