February 25, 2020
IIVS, in collaboration with EPAA, is pleased to announce that our training videos for eye irritation and phototoxicity are now available with Russian subtitles. To view subtitled versions in different languages including Chinese, Portuguese and Spanish, please visit our YouTube channel.
BCOP | Phototoxicity
October 17, 2019
The Transient Receptor Potential Vanilloid type 1 (TRPV1) receptor is one of the most well characterized pain-inducing receptors and has been recently identified as a valuable tool to predict eye stinging potential of surfactant based formulations. In this study we sought to predict eye stinging of nonsurfactant based cosmetic formulations by studying TRPV1 activity using the NociOcular assay. In the NociOcular assay, TRPV1 expressing neuroblastoma cells are exposed to test substance and TRPV1 activity is measured by acute increases in...
NociOcular Eye Sting | Cosmetic & Personal Care
September 13, 2019
The US EPA has committed to dramatically reducing animal testing with a commitment for total elimination by the year 2035.
IIVS is proud to have played a part in the move to reduce animal testing, starting with the successful development, and acceptance, of the non-animal eye-irritation defined approach, which was developed by an industry and regulatory consortium led by IIVS' CEO Rodger D. Curren, Ph.D.
IIVS looks forward to continuing its collaboration with stakeholders to help the agency achieve its goals.
BCOP | Eye Irritation Test | Ocular Screening
May 9, 2019
Gaithersburg, MD – May 8, 2019 – The Institute for In Vitro Sciences, Inc. (IIVS) has received a grant from the European Partnership for Alternative Approaches to Animal Testing (EPAA) to support its annual training of Chinese scientists in non-animal testing methods. As part of the agreement, two scientists from BASF SE, a member of EPAA, will join IIVS to provide hands-on training in China for four non-animal approaches for skin sensitization. This training follows the recent announcement by China’s...
DPRA | Short Time Exposure | Cosmetic & Personal Care | Alternative testing in China | Alternative Testing Methods | BASF SE | China | DPRA | EPAA | Erin Hill
April 3, 2019
Gaithersburg, MD – April 3, 2019 – The Institute for In Vitro Sciences (IIVS) applauds China’s National Medical Products Administration (NMPA) for their acceptance of certain non-animal (alternative) test methods for the regulation of cosmetics. In a notice issued on March 22, the NMPA drafted acceptance of nine test methods including:
Direct Peptide Reaction Assay (DPRA) for Skin Sensitization (OECD TG 442C)
Short Time Exposure Assay (STE) for eye irritation (OECD TG 491)
These new regulations will go into effect January...
DPRA | Short Time Exposure | Cosmetic & Personal Care | Alternative testing in China | Alternative Testing Methods | China | Erin Hill | NIFDC | NMPA | OECD TG 442C
March 22, 2019
We are pleased to share that today China’s National Medical Products Association (NMPA) has approved new methods for the regulations of cosmetics. Among these are two in vitro methods: DPRA for skin sensitization and the Short Time Exposure (STE) assay for eye irritation. IIVS’ International Outreach Program introduced these methods during its training program with NMPA and we will continue to support their implementation in key laboratories....
DPRA | Short Time Exposure | Cosmetic & Personal Care | Alternative Testing Methods | China
March 18, 2019
The selection of reference and proficiency chemicals is an important component of method validation and proficiency evaluations. Reference chemicals are a set of test substances used by a method developer to evaluate there liability and relevance of a new method, in comparison to reference data (usually to a validated reference method). Proficiency chemicals, as defined in OECD Guidance Document on Good In Vitro Method Practices, are defined post validation as a subset of the reference chemicals, or other chemicals with...
BCOP | Corrositex | BASF SE | Erin Hill | GIVIMP | Good In Vitro Method Practices | Hans Raabe | Robert Landsiedel | SOT 2019 | Susanne Kolle
February 21, 2019
Measures outlined in the Industrial Chemicals Bill 2017, passed by the Australian senate on 19 February, 2019, will apply to both imported and Australian produced chemicals for use as cosmetic ingredients. The commencement date is set for July 2020 although it is believed that the cosmetics industry will not need an entire year to implement changes to comply with the new law. Additionally, the bill includes funding for the development of alternative test methods.
Read the full article....
BCOP | Ocular Screening | Sensitization | Skin Irritation Test | Skin Sensitization | Cosmetic & Personal Care | Fragrance & Flavors | non-animal testing
October 17, 2018
By Amanda Lim, Editor (Singapore) CosmeticsDesign-Asia.com
Although China has made significant strides in moving away from animal testing, its challenges suggest it may take more than five years for the country to completely stop compulsory animal-testing for cosmetics, says Hedy He, regulatory analyst and editor of ChemLinked: "In the short term a total ban on animal testing is unlikely given the lack of testing infrastructure and technical capacity shortcomings of the industry."
The Overarching Issue
Among the many obstacles, the overarching one is the...
3T3 Neutral Red Uptake | BCOP | Phototoxicity | Sensitization | Cosmetic & Personal Care | alternatives to animal testing | China | Education & Outreach | skin sensitization