Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS | Assays Ocular
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Archive

Evaluation of TRPV1 Activity to Assess the Eye Stinging Potential of Cosmetic Formulations

October 17, 2019
The Transient Receptor Potential Vanilloid type 1 (TRPV1) receptor is one of the most well characterized pain-inducing receptors and has been recently identified as a valuable tool to predict eye stinging potential of surfactant based formulations. In this study we sought to predict eye stinging of nonsurfactant based cosmetic formulations by studying TRPV1 activity using the NociOcular assay. In the NociOcular assay, TRPV1 expressing neuroblastoma cells are exposed to test substance and TRPV1 activity is measured by acute increases in...

US EPA Commits to Dramatically Reduce Animal Testing

September 13, 2019
The US EPA has committed to dramatically reducing animal testing with a commitment for total elimination by the year 2035. IIVS is proud to have played a part in the move to reduce animal testing, starting with the successful development, and acceptance, of the non-animal eye-irritation defined approach, which was developed by an industry and regulatory consortium led by IIVS' CEO Rodger D. Curren, Ph.D. IIVS looks forward to continuing its collaboration with stakeholders to help the agency achieve its goals. Read the...

European Partnership Supports IIVS Training of Chinese Scientists in Non-animal Tests

May 9, 2019
Gaithersburg, MD – May 8, 2019 – The Institute for In Vitro Sciences, Inc. (IIVS) has received a grant from the European Partnership for Alternative Approaches to Animal Testing (EPAA) to support its annual training of Chinese scientists in non-animal testing methods. As part of the agreement, two scientists from BASF SE, a member of EPAA, will join IIVS to provide hands-on training in China for four non-animal approaches for skin sensitization. This training follows the recent announcement by China’s...

China’s Acceptance of Certain Non-Animal Testing Methods for the Regulation of Cosmetics

April 3, 2019
Gaithersburg, MD – April 3, 2019 – The Institute for In Vitro Sciences (IIVS) applauds China’s National Medical Products Administration (NMPA) for their acceptance of certain non-animal (alternative) test methods for the regulation of cosmetics. In a notice issued on March 22, the NMPA drafted acceptance of nine test methods including: Direct Peptide Reaction Assay (DPRA) for Skin Sensitization (OECD TG 442C) Short Time Exposure Assay (STE) for eye irritation (OECD TG 491) These new regulations will go into effect January...

China’s NMPA Approves Two New In Vitro Methods For Regulating Cosmetics

March 22, 2019
We are pleased to share that today China’s National Medical Products Association (NMPA) has approved new methods for the regulations of cosmetics.  Among these are two in vitro methods: DPRA for skin sensitization and the Short Time Exposure (STE) assay for eye irritation. IIVS’ International Outreach Program introduced these methods during its training program with NMPA and we will continue to support their implementation in key laboratories....

Regarding the References for Reference Chemicals of Alternative Methods

March 18, 2019
The selection of reference and proficiency chemicals is an important component of method validation and proficiency evaluations. Reference chemicals are a set of test substances used by a method developer to evaluate there liability and relevance of a new method, in comparison to reference data (usually to a validated reference method). Proficiency chemicals, as defined in OECD Guidance Document on Good In Vitro Method Practices, are defined post validation as a subset of the reference chemicals, or other chemicals with...

Australian Bill Passed to End Animal Testing for Cosmetics

February 21, 2019
Measures outlined in the Industrial Chemicals Bill 2017, passed by the Australian senate on 19 February, 2019, will apply to both imported and Australian produced chemicals for use as cosmetic ingredients. The commencement date is set for July 2020 although it is believed that the cosmetics industry will not need an entire year to implement changes to comply with the new law. Additionally, the bill includes funding for the development of alternative test methods. Read the full article....

China’s Compulsory Animal Testing for Cosmetics May Take More Than Five Years to Stop

October 17, 2018
By Amanda Lim, Editor (Singapore) CosmeticsDesign-Asia.com   Although China has made significant strides in moving away from animal testing, its challenges suggest it may take more than five years for the country to completely stop compulsory animal-testing for cosmetics, says Hedy He, regulatory analyst and editor of ChemLinked: "In the short term a total ban on animal testing is unlikely given the lack of testing infrastructure and technical capacity shortcomings of the industry." The Overarching Issue Among the many obstacles, the overarching one is the...

Strategies for Eye Irritation Testing

September 17, 2018
Determination of ocular irritation potential is a key toxicological endpoint required to support chemical and raw material characterization and industrial hygiene, to guide product development, and to achieve final product safety standards.  IIVS possesses extensive experience with numerous test methods and testing strategies for commercial, industrial and regulatory applications.  From standard regulatory hazard assessments to providing information on the degree of ocular irritation, to discriminating among extremely mild eye area products, IIVS’ Study Directors take the time to understand your...

Modernization of EPA “6-Pack” of Acute Toxicity Tests Continues

July 27, 2018
The US Environmental Protection Agency (US EPA) continues to drive significant efforts in the United States to modernize the battery of acute toxicity tests classically known as the “6-pack.” Learn More....