February 21, 2019Measures outlined in the Industrial Chemicals Bill 2017, passed by the Australian senate on 19 February, 2019, will apply to both imported and Australian produced chemicals for use as cosmetic ingredients. The commencement date is set for July 2020 although it is believed that the cosmetics industry will not need an entire year to implement changes to comply with the new law. Additionally, the bill includes funding for the development of alternative test methods.
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BCOP | Ocular Screening | Sensitization | Skin Irritation Test | Skin Sensitization | Cosmetic & Personal Care | Fragrance & Flavors | non-animal testing
July 23, 2018Read our latest publication with Bristol-Myers Squibb regarding a tiered testing strategy for occupational hazards of pharmaceutical intermediates now published in the Cutaneous and Ocular Toxicology Journal.
Irritation reactions are a frequently reported occupational illness. The potential adverse effects of pharmaceutical compounds (PCs) on employees' eyes and skin can now be assessed using validated in vitro methods.
Our overall aim is to reduce animal testing by replacing the historically utilized in vivo test methods with validated in vitro test methods which accurately determine the ocular...
BCOP | Corrositex | Irritation Screening | Skin Irritation Corrosion Screening | Skin Irritation Test | Pharmaceutical
March 30, 2017One of the current goals of the United States Environmental Protection Agency Office of Pesticide Programs (US EPA OPP) is to replace by non-animal testing methods as many of the endpoints of the battery of acute toxicity tests known as the “6-pack” as possible. One of the “6-pack” tests is the Draize rabbit test for dermal irritation. We investigated whether the validated in vitro Skin Irritation Test (SIT, OECD TG 439) can be used to determine US EPA OPP dermal...
Dermal | Skin Irritation Test | Agro/Petrochemical | Cosmetic & Personal Care
August 24, 2016Skin Irritation Test (SIT) in a Reconstructed Human Epidermis (RhE) Model
Skin Irritation in the regulatory hazard classification and labeling context is defined as the production of reversible damage to skin following a defined chemical exposure. The Skin Irritation Test (SIT) is an in vitro, non-animal test designed to identify those chemicals and mixtures capable of inducing moderate skin irritation (UN GHS Category 2 Skin Irritants1), and to discriminate UN GHS Category 2 Skin Irritants from UN GHS 3 mild skin...
Skin Irritation Test
August 24, 2016Specialty chemicals are chemical products identified on the basis of their performance or function, rather than their composition. They can be single-chemical entities or formulations and cover a wide range of product categories such as consumer products, cosmetics, food additives, manufacturing, etc.
As a result, testing for these chemicals can include a wide range in the irritation spectrum, from materials that are classified as mild irritants to those that are designated as corrosive. The testing needs also cover a wide range...
Reconstructed Skin Micronucleus (RSMN) | Skin Irritation Test | Cleaning Products
August 23, 2016The Corrositex® assay is a standardized and quantitative in vitro test developed as a replacement for the dermal corrosivity rabbit test. The Corrositex kit, manufactured by In Vitro International (IVI), uses a proprietary biobarrier membrane to model the skin for evaluating the potential dermal corrosivity of a test material.
A test material is evaluated based on its penetration through the biobarrier membrane into a Chemical Detection System (CDS). The time required for the test material to break through the biobarrier and into the CDS is...
Corrositex | Dermal | Skin Irritation Corrosion Screening | Skin Irritation Test