Archive

In Vitro Assessment of Skin Irritation Potential of Surfactant-based Formulations by Using a 3-D Skin Reconstructed Tissue Model and Cytokine Response

January 24, 2017
The personal care industry is focused on developing safe, more efficacious, and increasingly milder products, that are routinely undergoing preclinical and clinical testing before becoming available for consumer use on skin. In vitro systems based on skin reconstructed equivalents are now established for the preclinical assessment of product irritation potential and as alternative testing methods to the classic Draize rabbit skin irritation test. We have used the 3-D EpiDerm™ model system to evaluate tissue viability and primary cytokine interleukin-1α release... Corrositex | Dermal | Inflammatory Cytokine Expression | Irritation Screening | Pigmentation & Melanogenesis | Skin Corrosion Test | Skin Irritation Corrosion Screening | Skin Irritation Test | Skin Sensitization | UV Induced Toxicity

Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology

October 18, 2016
This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides... 3T3 Neutral Red Uptake | Acute Respiratory Toxicity | Assessing Corneal Recovery | BCOP | Bronchial/Tracheal | CAMVA | Chronic Respiratory Toxicity | Ciliary Beat Frequency | Corneal Recovery Modeling | Corrositex

Inflammatory Cytokine Expression

August 24, 2016
Many manufacturers of personal care and cosmetic products expect (along with their customers) that their products will not irritate the skin. Unfortunately, many ingredients (e.g. surfactants, preservatives, emulsifiers and many other organic substances) have an inherent irritating property. Although other in vitro assays can predict irritancy vs. non-irritancy for purposes of regulatory compliance, many of these manufacturers need to differentiate between moderately irritating substances and those which are much milder. Some examples are: baby products, moisturizers or other products used... Inflammatory Cytokine Expression | Cosmetic & Personal Care | interleukin IL-1α | mild-irritant | Mildness Assay | minimal-irritant | non-irritant | Predicting Irritancy

Next Generation Tobacco Products

August 24, 2016
IIVS has a long-standing history of working with various industries to help establish or utilize in vitro models for the prediction of risk and the assessment of products under development. With the Food and Drug Administration extending its authority to all tobacco products (including e-cigarettes, cigars, and hookah) the tobacco industry is faced with the task of assessing product safety for product development and regulatory submission. Further, the manufacture of tobacco products may entail risk to workers that come in... 3T3 Neutral Red Uptake | Acute Respiratory Toxicity | Bronchial/Tracheal | Chronic Respiratory Toxicity | Ciliary Beat Frequency | DPRA | Eye Irritation Test | Goblet Cell Hyperplasia | Inflammatory Biomarker Profiling | Inflammatory Cytokine Expression

Cytokine induction in the 3D EpiDerm™ skin model used as an in vitro preclinical screening tool for formulations with anti-inflammatory action

Toxic Insult to Rat Precision Cut Lung Slices Increases Tissue Cytokine Levels and Activation of Macrophages, and Causes Acute Damage, While Prolonged Insult May Lead to Increased Deposition of Collagen – a Marker of Fibrosis

December 1, 2014
Source: Assessment of In Vitro COPD Models for Tobacco Regulatory Science... Bronchial/Tracheal | Inflammatory Cytokine Expression | Precision Cut Lung Slices (PCLS) | Tobacco

The Use of Precision-cut Lung Slices to Assess Inflammation, Parenchymal Damage, and Collagen Deposition: Three Markers of Tobacco Exposure-induced Pulmonary Toxicity