Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS | Assays BCOP
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Archive

US EPA Commits to Dramatically Reduce Animal Testing

September 13, 2019
The US EPA has committed to dramatically reducing animal testing with a commitment for total elimination by the year 2035. IIVS is proud to have played a part in the move to reduce animal testing, starting with the successful development, and acceptance, of the non-animal eye-irritation defined approach, which was developed by an industry and regulatory consortium led by IIVS' CEO Rodger D. Curren, Ph.D. IIVS looks forward to continuing its collaboration with stakeholders to help the agency achieve its goals. Read the...

Regarding the References for Reference Chemicals of Alternative Methods

March 18, 2019
The selection of reference and proficiency chemicals is an important component of method validation and proficiency evaluations. Reference chemicals are a set of test substances used by a method developer to evaluate there liability and relevance of a new method, in comparison to reference data (usually to a validated reference method). Proficiency chemicals, as defined in OECD Guidance Document on Good In Vitro Method Practices, are defined post validation as a subset of the reference chemicals, or other chemicals with...

Australian Bill Passed to End Animal Testing for Cosmetics

February 21, 2019
Measures outlined in the Industrial Chemicals Bill 2017, passed by the Australian senate on 19 February, 2019, will apply to both imported and Australian produced chemicals for use as cosmetic ingredients. The commencement date is set for July 2020 although it is believed that the cosmetics industry will not need an entire year to implement changes to comply with the new law. Additionally, the bill includes funding for the development of alternative test methods. Read the full article....

China’s Compulsory Animal Testing for Cosmetics May Take More Than Five Years to Stop

October 17, 2018
By Amanda Lim, Editor (Singapore) CosmeticsDesign-Asia.com   Although China has made significant strides in moving away from animal testing, its challenges suggest it may take more than five years for the country to completely stop compulsory animal-testing for cosmetics, says Hedy He, regulatory analyst and editor of ChemLinked: "In the short term a total ban on animal testing is unlikely given the lack of testing infrastructure and technical capacity shortcomings of the industry." The Overarching Issue Among the many obstacles, the overarching one is the...

Strategies for Eye Irritation Testing

September 17, 2018
Determination of ocular irritation potential is a key toxicological endpoint required to support chemical and raw material characterization and industrial hygiene, to guide product development, and to achieve final product safety standards.  IIVS possesses extensive experience with numerous test methods and testing strategies for commercial, industrial and regulatory applications.  From standard regulatory hazard assessments to providing information on the degree of ocular irritation, to discriminating among extremely mild eye area products, IIVS’ Study Directors take the time to understand your...

Modernization of EPA “6-Pack” of Acute Toxicity Tests Continues

July 27, 2018
The US Environmental Protection Agency (US EPA) continues to drive significant efforts in the United States to modernize the battery of acute toxicity tests classically known as the “6-pack.” Learn More....

Modernization of EPA “6-Pack” of Acute Toxicity Tests Continues

July 26, 2018
The US Environmental Protection Agency (US EPA) continues to drive significant efforts in the United States to modernize the battery of acute toxicity tests classically known as the “6-pack.” Known for many years as an “all in vivo” testing strategy for products registered under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), the 6-pack was revised in 2015 to include non-animal (in vitro/ex vivo) test methods for classification and labeling for Eye Irritation, both for commonly used household cleaning products...

Tiered In Vitro Testing Strategy For Assessing The Ocular and Dermal Irritation/Corrosion Potential of Pharmaceutical Compounds

July 23, 2018
Read our latest publication with Bristol-Myers Squibb regarding a tiered testing strategy for occupational hazards of pharmaceutical intermediates now published in the Cutaneous and Ocular Toxicology Journal. Irritation reactions are a frequently reported occupational illness. The potential adverse effects of pharmaceutical compounds (PCs) on employees' eyes and skin can now be assessed using validated in vitro methods. Our overall aim is to reduce animal testing by replacing the historically utilized in vivo test methods with validated in vitro test methods which accurately determine the ocular...

Video: Bovine Corneal Opacity & Permeability Test – Spanish

October 16, 2017
This 13- minute training video demonstrates how to perform the BCOP assay according to the Test Guidelines set forth for the assay by the Organization for Economic Co-operation and Development (OECD TG 437). The video focuses on steps that are critical to the success of the assay such as handling of the isolated cornea and removal of the test material from the cornea at the conclusion of the exposure time. ...

Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology

October 18, 2016
This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides...