May 2022

Eye Irritation Testing and Beyond

May 18, 2022
If you missed the webinar: Establishing Scientific Confidence in New Approach Methodologies (NAMs): Eye Irritation Testing and Beyond, co-sponsored by the Risk Assessment and In Vitro and Alternative Methods Specialty Sections of SOT, a recording is now posted. Speakers included Hans Raabe (IIVS) and Dr. Amy Clippinger, (PETA International Science Consortium e.V.)....

IIVS Posters at SOT 2022

April 14, 2022
Thank you to all who visited our booth or poster sessions at the 2022 Society of Toxicology annual meeting. If you would like copies of any of the poster presented we now have them available to view online: Compatibility Determination of Alternative Solvents in the human Cell Line Activation Test (h-CLAT) for the Assessment of Skin Sensitization Cryopreservation of Human Precision-Cut Lung Slices Provides an Immune Competent, Pulmonary Test System for “On-Demand” Use Modification in Procedure of the Reconstructed Human EpiDermis (RhE) Phototoxicity Assay Improving...

Evaluating the Use of Predictive Models in Combination with In Vitro Assays

April 11, 2022
IIVS is excited to announce the publication of 2 papers evaluating the use of predictive models in combination with in vitro assays to provide a quantitative assessment of skin sensitization potential. This work is presented Drs. Frank Gerberick (GF3 Consultancy, Chief Scientific Advisor to IIVS) and Andreas Natsch (Senior Research Fellow at Givaudan ) Integrated Skin Sensitization Assessment Based on OECD Methods (I): Deriving a Point of Departure for Risk Assessment Integrated Skin Sensitization Assessment Based on OECD Methods(II): Hazard and Potency...

Use of alternative test methods in a tiered testing approach to address photoirritation potential of fragrance materials

January 3, 2022
Happy New Year! IIVS is pleased to greet 2022 with the announcement of a joint publication with the Research Institute for Fragrance Materials (RIFM) involving the evaluation of photoirritation potential of over 100 compounds. This effort, spanning the course of 7 years, involved a tiered testing approach with the application of 3 OECD test guidelines: TG 101, 432 and the recently accepted 498, which codifies the acceptance of Reconstructed human Epidermis as a model for assessing this endpoint. Read the full...