April 2022

Evaluating the Use of Predictive Models in Combination with In Vitro Assays

April 11, 2022
IIVS is excited to announce the publication of 2 papers evaluating the use of predictive models in combination with in vitro assays to provide a quantitative assessment of skin sensitization potential. This work is presented Drs. Frank Gerberick (GF3 Consultancy, Chief Scientific Advisor to IIVS) and Andreas Natsch (Senior Research Fellow at Givaudan ) Integrated Skin Sensitization Assessment Based on OECD Methods (I): Deriving a Point of Departure for Risk Assessment Integrated Skin Sensitization Assessment Based on OECD Methods(II): Hazard and Potency...

Use of alternative test methods in a tiered testing approach to address photoirritation potential of fragrance materials

January 3, 2022
Happy New Year! IIVS is pleased to greet 2022 with the announcement of a joint publication with the Research Institute for Fragrance Materials (RIFM) involving the evaluation of photoirritation potential of over 100 compounds. This effort, spanning the course of 7 years, involved a tiered testing approach with the application of 3 OECD test guidelines: TG 101, 432 and the recently accepted 498, which codifies the acceptance of Reconstructed human Epidermis as a model for assessing this endpoint. Read the full...