Genetic Toxicology
Reconstructed Skin Micronucleus (RSMN)
Reconstructed Skin Micronucleus (RSMN) Using the EpiDerm™ Reconstructed Human Epidermis Model RSMN is used to evaluate the genotoxicity potential of the test article to the EpiDerm™ Skin Model. Genotoxicity potential is determined by assessing whether the micronucleus frequency in tissues exposed to the test article showed a statistically significant increase relative to the tissues exposed...
Bhas 42 Cell Transformation Assay
Bhas 42 Cell Transformation Assay (Bhas 42 CTA) The Bhas 42 CTA is used to evaluate the carcinogenic potential (tumor-initiating activity and/or -promoting activity) of genotoxic or non-genotoxic test articles. The untransformed Bhas 42 cells grow to confluence forming a density-dependent contact-inhibited monolayer. A carcinogenic stimulus induces morphological alterations and leads to the formation of...
ToxTracker®
Learn More About This Assay in Our August 15-16 Practical Methods Workshop ToxTracker® is a unique, stem-cell based assay which takes advantage of a Green Fluorescent Protein (GFP) reporter system to identify hazard and mode-of-action (MOA) of potentially genotoxic materials. ToxTracker has been extensively validated to predict in vivo genotoxic substances with an accuracy of...
Indigo Biosciences Nuclear Receptor
The Indigo Biosciences Nuclear Receptor (NR) assays offer a fast and accurate way to screen candidate chemicals or ingredients for potential interactions that can disrupt normal biological processes, by binding to receptors on the nuclear membrane. Discover agonist and antagonist potentials of known and new substances, whether you are running high-throughput on-target drug discovery or...