Archive

21 Jun Characterization of a Vitrocell VC1 Using Nicotine Dosimetry: An Essential Component Toward Standardized In Vitro Aerosol Exposure of Tobacco and Next Generation Nicotine Delivery Products

Posted at 18:25h in Uncategorized by Jane Ryan 0 Comments

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The U.S. Food and Drug Administration has regulatory authority over tobacco products, including conventional cigarettes and next generation products (NGPs) such as e-cigarettes and tobacco heating products (THPs). There is a desire by the industry, regulators and animal protection organizations to incorporate non-animal test methods for tobacco product and...

18 Jun Abstract Deadline Extended for ESTIV 2018

Posted at 14:02h in Uncategorized by Jane Ryan 0 Comments

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The 20th International Congress on In Vitro Toxicology (ESTIV2018) happening in Berlin, 15-18 October, has extended their abstract submission deadline to July 1. Several grants and bursaries are also still open to applicants until July 1, including the PETA International Science Consortium early-career scientist award. Learn more about the...

14 Jun Holger Behrsing, PhD, Participates in Round Table Discussion on Non-Animal Approaches for Inhalation Toxicology

Posted at 21:31h in Uncategorized by Jane Ryan 0 Comments

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Holger Behrsing, PhD, was recently invited to participate in an expert round table discussion convened on the development and implementation of 21st century non-animal approaches to assess the toxicity of inhaled substances. The discussion included perspectives from government, industry, nonprofit, and academic sectors on the...

12 Apr New Studies Demonstrate Risk Reduction Potential of Heat-Not-Burn Tobacco Products and e-Cigarettes

Posted at 15:47h in Uncategorized by Jane Ryan 0 Comments

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IIVS, in collaboration with Philip Morris International, recently presented data highlighting the predictive capability of in vitro assays in determining human response to non-burn tobacco products. Moreover, a ring trial of 6 independent laboratories has generated evidence that key events involved in human disease caused...

28 Mar Human In Vitro Models for Respiratory Toxicology: Evaluation of Goblet Cell Hyperplasia, Mucus Production, and Ciliary Beating Assays

Posted at 16:55h in Uncategorized by Jane Ryan 0 Comments

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Robust non-animal models and assays for pulmonary toxicology are required to make competent product development and risk assessments for new materials requiring toxicity testing. Three in vitro assays (goblet cell hyperplasia [GCH], ciliary beat frequency [CBF], and MUC5AC quantitation) were evaluated for performance and reproducibility....

28 Mar Use of Ex Vivo Precision-Cut Lung Slices as a Screening Tool for Potential Respiratory Toxicity of E-Liquids

Posted at 16:44h in Uncategorized by Jane Ryan 0 Comments

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E-vapor product liquids contain a variety of ingredient combinations that should be assessed for human risk. One human lung-relevant testing platform with reasonable throughput, is human precision-cut lung slices (HuPCLS). HuPCLS are arguably the most complex non-animal model of the lung, retaining native architecture and...

28 Mar Oral Irritation Assessment of Electronic Liquids Using an In Vitro Oral Testing Model

Posted at 16:32h in Uncategorized by Jane Ryan 0 Comments

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While data are still being collected and analyzed, there were at least 1,300 accidental electronic liquid (e-liquid) exposures reported as of 2013. Deaths have occurred as a result of ingestion of e-liquid with the effects being attributed primarily to nicotine. The Food and Drug Administration (FDA)...

28 Mar Nicotine Characterization of an In Vitro Inhalation Exposure System Using Conventional and Next-Generation Tobacco Products: A US/UK Inter-Laboratory Comparison

Posted at 16:08h in Uncategorized by Jane Ryan 0 Comments

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The US-FDA has regulatory authority over tobacco products, including conventional cigarettes and next generation products (NGPs) such as e-cigarettes and tobacco heating products (THPs). There is a desire by the industry, regulator and animal protection organizations to incorporate non-animal test methods for tobacco product and NGP assessment....

08 Feb IIVS at SOT 2018

Posted at 17:32h in Uncategorized by Jane Ryan 0 Comments

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IIVS will have several events and posters at the upcoming SOT meeting, March 11-15, in San Antonio, TX. The events and three of our five posters focus on our respiratory toxicology program in support of our new laboratory that opened in 2017. Other posters examine...

28 Aug Quality Considerations: Redefining Test Systems from Animals to Tissues and Beyond

Posted at 17:12h in Uncategorized by Jane Ryan 0 Comments

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The use of non-whole animal test methods transforms the way regulatory requirements are applied in preclinical testing. Recent global regulatory initiatives emphasize the importance of transitioning to human relevant assays and test systems that do not use animals. When these methods are moved from research...