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Publication: Standards of Good Practices for the Conduct of In Vitro Toxicity Studies
The field of in vitro toxicity studies presents the opportunity for great innovation while providing…
Publication: Advanced In Vitro Systems Available for Respiratory Toxicology
Increasing concerns in respect to the transferability of data from animal studies to real human…
Publication: Assessment of Phototoxicity Potential of Botanicals as Cosmetic Ingredients Using the In Vitro 3T3 Neutral Red Uptake Phototoxicity Test
Cosmetics and personal care products are frequently formulated with botanical ingredients due to their beneficial…
Publication: New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches
Skin sensitization is a complex biological process induced by a wide range of chemicals, from…
Publication: A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods
There is increased interest in developing non-animal test systems for inhalation exposure safety assessments. However,…
Publication: New Approach Methodologies (NAMs) for the In Vitro Assessment of Cleaning Products for Respiratory Irritation: Workshop Report
The use of in vitro new approach methodologies (NAMs) to assess respiratory irritation depends on…
Publication: Evaluation of a Non-Animal Toolbox Informed by Adverse Outcome Pathways for Human Inhalation Safety
This work evaluated a non-animal toolbox to be used within a next-generation risk assessment (NGRA)…
Publication: Development of Preliminary Candidate Surface Guidelines for Air Force-Relevant Dermal Sensitizers Using New Approach Methodologies
Allergic contact dermatitis (ACD) is an immunologic reaction to a dermal chemical ex-posure that, once…
Publication: Optimizations of the Reconstructed Human Epidermis-Based Phototoxicity Testing to Evaluate the Safety of Long-Lasting Cosmetic Products
The safety of cosmetic products coming in contact with consumers’ skin is often assessed using…
Publication: A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods
There is increased interest in developing non-animal test systems for inhalation exposure safety assessments. However,…
Publication: Human relevance of in vivo and in vitro skin irritation tests for hazard classification of pesticides
Test methods to inform hazard characterization and labeling of pesticides to protect human health are…
Publication: The Fibrotic Phenotype of Human Precision-Cut Lung Slices Is Maintained after Cryopreservation
Human precision-cut lung slices (hPCLS) prepared from fibrotic lungs recapitulate the pathophysiological hallmarks of fibrosis.…
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