Results
A Decision Tree For Acute Oral Toxicity: Implementing The Last Resort Requirement In Practice
September 22, 2026 PublicationAcute oral toxicity (AOT) testing is widely used for hazard identification in chemical safety assessment, but traditional animal methods are…
A Proposed Evaluation Of New Approach Methodologies For Dermal Toxicity Assessment Of Botanicals
September 22, 2026 PublicationBotanicals are widely used in topical formulations for cosmetics, hair care, and personal care products, reflecting consumer interest in plant-derived…
Lost In Nams-Lation: A Review Of Animal-Free Science Definitions
September 22, 2026 PublicationThe use of terminology related to animal-free science has grown rapidly over the past two decades; however, definitions and interpretations…
Key Challenges For In Vitro Testing Of Oral Tobacco And Nicotine Products For Regulatory Applications: Recommendations For Using In Vitro Toxicity And Disease Models
September 22, 2026 PublicationThe Institute for In Vitro Sciences (IIVS) has sponsored a series of workshops with the aim of developing recommendations for…
Key Challenges For In Vitro Testing Of Tobacco And Next Generation Products For Regulatory Applications: Recommendations For The Ames Test
September 22, 2026 PublicationThe Ames bacterial mutagenesis assay (Ames test) has been used for more than 50 years, to help assess the safety…
Defining Benchmarking in the Context of Safety Assessment of Personal Care and Cosmetic Products
August 3, 2026 PublicationThe concept of benchmark materials in the personal care and cosmetic industry is often based on the positioning of prototypes…
Next-Generation Full-Thickness Human Skin Models Produced Using 3D Electrospun Scaffolds
August 3, 2026 PublicationIn vitro full-thickness human skin (FT-Skin) models are important tools for testing of cosmetics and chemicals, screening of new pharmaceuticals,…
Creating a Database of Reconstructed Oral Tissue Model Applications for Personal Care Industry and Beyond
August 3, 2026 PublicationThe personal care industry is an ever-expanding field of products that come into contact with our mouths daily, such as…
Using a Reconstructed Human Vaginal Epithelium Model to Assess Irritation
August 3, 2026 PublicationConsumers tend to think of personal lubricants as personal care products or cosmetics that are not tested using animals, but…
Confidence in New Approach Methods (NAMs)
August 3, 2026 PublicationReproducibility including independent ring trials remain essential for regulatory confidence in NAMs. Validation reform must not compromise data quality, robustness,…
The Impossible Made Possible Through the use of New Approach Methodologies
August 3, 2026 PublicationToxicological profiling is a critical component of the regulatory process required to inform the hazard characterisation and labelling of chemicals,…
Standards of Good Practices for the Conduct of In Vitro Toxicity Studies
December 19, 2025 PublicationThe field of in vitro toxicity studies presents the opportunity for great innovation while providing many scientific challenges. This chapter…