Evaluation of a Non-Animal Toolbox Informed by Adverse Outcome Pathways for Human Inhalation Safety

This work evaluated a non-animal toolbox to be used within a next-generation risk assessment (NGRA) framework to assess chemical-induced lung…

Development of Preliminary Candidate Surface Guidelines for Air Force-Relevant Dermal Sensitizers Using New Approach Methodologies

Allergic contact dermatitis (ACD) is an immunologic reaction to a dermal chemical ex-posure that, once triggered in an individual, will…

Optimizations of the Reconstructed Human Epidermis-Based Phototoxicity Testing to Evaluate the Safety of Long-Lasting Cosmetic Products

The safety of cosmetic products coming in contact with consumers’ skin is often assessed using New Approach Methodologies, which include…

A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods

There is increased interest in developing non-animal test systems for inhalation exposure safety assessments. However, defined methodologies are absent for…

Human relevance of in vivo and in vitro skin irritation tests for hazard classification of pesticides

Test methods to inform hazard characterization and labeling of pesticides to protect human health are typically conducted using laboratory animals,…

The Fibrotic Phenotype of Human Precision-Cut Lung Slices Is Maintained after Cryopreservation

Human precision-cut lung slices (hPCLS) prepared from fibrotic lungs recapitulate the pathophysiological hallmarks of fibrosis. These hallmark features can also…

Deriving a point of departure for assessing the skin sensitization risk of wearable device constituents with in vitro methods

Wearable devices are in contact with the skin for extended periods. As such, the device constituents should be evaluated for…

The Importance of Supplier Qualification for Vendors of Materials Used in In Vitro Assays

Pre-clinical assays, including in vitro assays, rely heavily on suppliers who provide essential products or services. In the current regulatory…

Cryopreserved human precision-cut lung slices provide an immune competent pulmonary test system for “on-demand” use and long-term cultures

Human precision-cut lung slices (hPCLS), considered a highly relevant ex vivo model of the lung, offer native architecture and cells…

Multiscale Stiffness of Human Emphysematous Precision-Cut Lung Slices

IIVS is excited to announce a new publication in Science with co-authors at Boston University and Mechanobiologix (Newton, MA, USA)!…

IIVS Financial Conflict of Interest in Research Policy

Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters

The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to identify, discuss and develop recommendations for…