Results
Advanced In Vitro Systems Available for Respiratory Toxicology
December 19, 2025 PublicationIncreasing concerns in respect to the transferability of data from animal studies to real human health effects further supported by…
Assessment of Phototoxicity Potential of Botanicals as Cosmetic Ingredients Using the In Vitro 3T3 Neutral Red Uptake Phototoxicity Test
December 19, 2025 PublicationCosmetics and personal care products are frequently formulated with botanical ingredients due to their beneficial properties, the nature of their…
New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches
December 19, 2025 PublicationSkin sensitization is a complex biological process induced by a wide range of chemicals, from single molecules to complex mixtures…
A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods
December 19, 2025 PublicationThere is increased interest in developing non-animal test systems for inhalation exposure safety assessments. However, defined methodologies are absent for…
New Approach Methodologies (NAMs) for the In Vitro Assessment of Cleaning Products for Respiratory Irritation: Workshop Report
August 22, 2025 PublicationThe use of in vitro new approach methodologies (NAMs) to assess respiratory irritation depends on several factors, including the speci…
Evaluation of a Non-Animal Toolbox Informed by Adverse Outcome Pathways for Human Inhalation Safety
August 22, 2025 PublicationThis work evaluated a non-animal toolbox to be used within a next-generation risk assessment (NGRA) framework to assess chemical-induced lung…
Development of Preliminary Candidate Surface Guidelines for Air Force-Relevant Dermal Sensitizers Using New Approach Methodologies
August 22, 2025 PublicationAllergic contact dermatitis (ACD) is an immunologic reaction to a dermal chemical ex-posure that, once triggered in an individual, will…
Optimizations of the Reconstructed Human Epidermis-Based Phototoxicity Testing to Evaluate the Safety of Long-Lasting Cosmetic Products
January 10, 2025 PublicationThe safety of cosmetic products coming in contact with consumers’ skin is often assessed using New Approach Methodologies, which include…
A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods
January 8, 2025 PublicationThere is increased interest in developing non-animal test systems for inhalation exposure safety assessments. However, defined methodologies are absent for…
Human relevance of in vivo and in vitro skin irritation tests for hazard classification of pesticides
September 24, 2024 PublicationTest methods to inform hazard characterization and labeling of pesticides to protect human health are typically conducted using laboratory animals,…
The Fibrotic Phenotype of Human Precision-Cut Lung Slices Is Maintained after Cryopreservation
September 24, 2024 PublicationHuman precision-cut lung slices (hPCLS) prepared from fibrotic lungs recapitulate the pathophysiological hallmarks of fibrosis. These hallmark features can also…
Deriving a point of departure for assessing the skin sensitization risk of wearable device constituents with in vitro methods
September 24, 2024 PublicationWearable devices are in contact with the skin for extended periods. As such, the device constituents should be evaluated for…